Evidence map›Paper›PMID 41097878›Full record

ArticleBrain and behavior2025

Early Postnatal Infection With Human Cytomegalovirus Has Long-Term Consequences on Brain Structure of Former Preterm Born Children.

Meike Müller, Karen Lidzba, Christian Gaser, Till-Karsten Hauser, Rangmar Goelz, Klaus Hamprecht, Marko Wilke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meike MüllerDepartment of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital Tübingen, Tübingen, Germany.
Karen LidzbaDivision of Neuropaediatrics, Development and Rehabilitation, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Christian GaserDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Till-Karsten HauserDepartment of Neuroradiology, University Hospital Tübingen, Tubingen, Germany.
Rangmar GoelzDepartment of Neonatology, University Children's Hospital Tübingen, Tubingen, Germany.
Klaus HamprechtInstitute For Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tubingen, Germany.
Marko WilkeDepartment of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0001-5655-027X

Funding

Deutsche Forschungsgemeinschaft WI 3630/1-1Deutsche Forschungsgemeinschaft WI 3630/1-2Medizinische Fakultät der Eberhard Karls Universität Tübingen IZKF Promotionskolleg 2016/1OpenAcces Fund, University of Tübingen
6 · The paper itself

Abstract

purposeCongenital infection with human Cytomegalovirus (hCMV) is a common cause of severe neurodevelopmental disability, while postnatal infection of a term-born infant will usually not lead to an adverse neurodevelopmental outcome. In preterm-born infants, long-term consequences of an early postnatal hCMV infection (usually via breast milk) are still controversial. This is highly relevant as preventative measures exist.

methodsData of 37 preterm-born children (PT; ≤ 32 weeks of gestation and/or weighing ≤ 1500 g) was included. Of these, 14 acquired an early postnatal infection with hCMV (PT

findingsCompared to FT, PT showed lower global gray matter (GM); interestingly, PT

conclusionWe found lower global and local GM volumes due to of prematurity. Additionally, we demonstrate long-term effects of early postnatal hCMV infection on brain structure in PT, markedly different from those resulting from prematurity alone. This suggests distinct long-term cerebral consequences of early postnatal hCMV infection in former preterm-born children above and beyond those attributable to prematurity. Consequently, efforts to avoid HCMV infection in preterm-born infants should be implemented.

Indexed as

BrainCytomegalovirus InfectionsAdolescentChildCytomegalovirusFemaleGray MatterHumansInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMaleMRI surface analysesMRI volumetric analysespostnatal human Cytomegalovirus infectionpremature birth

Identifiers

PMID41097878
PMCPMC12528545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.