Evidence map›Paper›PMID 41097873›Full record

ArticleJournal of genetic counseling2025

Psychosocial predictors of hereditary cancer genetic testing motivation in untested individuals.

Sarah Austin, Emerson Delacroix, John D Rice, Erika Koeppe, Elena M Stoffel, Jennifer J Griggs, Kenneth Resnicow

Abstract read
In one paragraph

Article in Journal of genetic counseling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah AustinDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4484-9746
Emerson DelacroixDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
John D RiceSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Erika KoeppeDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9775-6327
Elena M StoffelDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Jennifer J GriggsDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Kenneth ResnicowRogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Innovative Approaches to Expand Cancer Genetic Screening and Testing for Patients & Families in a Statewide Oncology Network through Community, State, & Payer PartnershipsU01CA232827 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRIGGS, JENNIFER J, RESNICOW, KEN A. · 2020 to 2020
$4.0M
NCI NIH HHS P30 CA046592NCI NIH HHS U01 CA232827
6 · The paper itself

Abstract

Genetic testing for hereditary cancer syndromes can provide lifesaving information allowing for individualized cancer screening, prevention, and treatment. A broader understanding of how psychosocial factors impact motivation to undergo genetic testing is needed to improve uptake among individuals who would benefit from testing. Adults (≥18 years) who met criteria for genetic testing based on a self-reported family cancer history and had not previously completed testing were invited to complete a survey (n = 799) assessing psychosocial factors including barriers to genetic testing, healthcare distrust, perceived self-efficacy, clinician autonomy support, and genetic testing knowledge. Associations between these psychosocial factors and testing motivation were examined first by correlation followed by multivariable linear regression. Self-efficacy had a significant positive correlation with genetic testing motivation, while barriers and healthcare distrust were negatively correlated with motivation. In an adjusted multivariable regression model, higher self-efficacy was associated with higher motivation while higher barriers and healthcare distrust were negatively associated with genetic testing motivation. Individuals of older age (51+), non-White race, and lower perceived socioeconomic status reported higher mean motivation scores. The negative association between distrust and barriers with genetic testing intention may be a potential target for tailored interventions for genetic testing.

Indexed as

Genetic TestingMotivationNeoplasmsAdultAgedFemaleHumansMaleMiddle AgedSelf Efficacygenetic testinghealthcare distrusthereditary cancer

Identifiers

PMID41097873
PMCPMC12528973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.