Evidence map›Paper›PMID 41097840›Full record

ArticleAdvanced healthcare materials2026

Vibration-Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis.

Xin Song, Kimberly Seaman, Amel Sassi, Chun-Yu Lin, Tiankuo Chu, Liyun Wang, Yu Sun, Lidan You

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin SongDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.ORCID 0000-0003-0313-1631
Kimberly SeamanDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.
Amel SassiInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Chun-Yu LinInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Tiankuo ChuDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
Liyun WangDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
Yu SunDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.
Lidan YouDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.ORCID 0000-0001-8889-4173

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2019-07056
6 · The paper itself

Abstract

Radiotherapy is a cornerstone of breast cancer treatment, but it can unintentionally damage bone, causing bone loss and pain, with no currently effective therapeutic strategy available. While chemically mediated radioprotection is extensively studied, mechanically mediated radioprotection remains underexplored. Given its safety and efficacy, this work examines the potential of low-magnitude, high-frequency (LMHF) vibration as a non-invasive intervention to protect irradiated bone, focusing on osteocytes-the primary mechanosensors and regulators whose functions extend to modulating breast cancer bone metastasis. These results demonstrate that LMHF vibration (0.3 g, 60 Hz, 1 h) mitigates osteocyte apoptosis and upregulates cytoskeletal markers following 8 Gy irradiation. LMHF vibration applied 1 h per day over 3 days restores the regulatory function of irradiated osteocytes in controlling breast cancer extravasation in a microfluidic platform. A combined approach integrating vibration with radiotherapy further reduces cancer invasion and extravasation, demonstrating a compound effect. RNA sequencing (RNA-seq) analysis reveals that this osteocyte-mediated regulation is possibly driven by the Wnt signaling pathway. These findings highlight the potential of LMHF vibration in enhancing radiotherapy efficacy by protecting osteocytes and reducing breast cancer metastasis, underscoring the promise of a non-invasive mechanical intervention in preserving bone health and optimizing cancer treatment outcomes.

Indexed as

Bone NeoplasmsBreast NeoplasmsOsteocytesVibrationAnimalsApoptosisCell Line, TumorFemaleHumansMicebreast cancermechanobiologymicrofluidicsosteocytesradiotherapy

Identifiers

PMID41097840
PMCPMC12836450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.