Evidence map›Paper›PMID 41097816›Full record

ArticleBrain and behavior2025

AQP4-ab-Positive Neuromyelitis Optica Spectrum Disorder Increases the Risk of Hydrocephalus: A Bidirectional Mendelian Randomization Study.

Weitao Zhong, Weisong Li, Qiwei Huang, Zelin Li, Qiang Wang, Wangming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weitao ZhongNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID 0009-0002-4085-8186
Weisong LiNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Qiwei HuangNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zelin LiNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Qiang WangNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wangming ZhangNeurosurgery Center, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSome observational studies indicated that AQP4-ab-positive neuromyelitis optica spectrum disorder (NMOSD) may predispose to hydrocephalus. However, the causal relationship between NMOSD and hydrocephalus remains elusive. We used bidirectional Mendelian randomization (MR) to examine the causal effect of AQP4-ab-positive NMOSD and hydrocephalus.

methodsThe exposure GWAS data used in this study were obtained from the GWAS Catalog, which included 132 AQP4-ab-positive patients and 1244 normal controls. The outcome GWAS data for hydrocephalus (N_

resultsIn the IVW analysis, we found that genetically predicted AQP4-ab-positive NMOSD was significantly associated with the increasing risk of hydrocephalus (OR = 1.05; 95% CI: 1.02-1.08; p = 7.65 × 10 DISCUSSION: Our results indicate that genetically predicted AQP4-ab-positive NMOSD significantly increases the risk of hydrocephalus. The reduced immune activity of AQP4 may play an important role in the pathogenesis of hydrocephalus.

Indexed as

Aquaporin 4HydrocephalusNeuromyelitis OpticaAutoantibodiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisAQP4 protein, humanAquaporin 4AutoantibodiesAQP4hydrocephalusMendelian randomizationneuromyelitis optica spectrum disorder

Identifiers

PMID41097816
PMCPMC12527984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.