Evidence map›Paper›PMID 41097811›Full record

ArticlePharmaceutical biology2025

Adjuvant potential of

Marah Alburqan, Annamária Kincses, Melinda Paizs, Anita Barta, Katalin Veres, Antal Csámpai, Morteza Yazdani, Judit Hohmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current Knowledge of the GenusPharmaceuticals (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marah AlburqanInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Annamária KincsesInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Melinda PaizsInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Anita BartaInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Katalin VeresInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Antal CsámpaiDepartment of Organic Chemistry, Eötvös Loránd University, Budapest, Hungary.
Morteza YazdaniHUN-REN - USZ Biologically Active Natural Products Research Group, University of Szeged, Szeged, Hungary.
Judit HohmannInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe global rise in bacterial resistance to existing antibiotics has led to increased mortality rates and escalating healthcare costs, underscoring the urgent need for new classes of antibacterial agents that can act synergistically with current antimicrobials.

objectiveThis study aimed to isolate bioactive compounds from MATERIALS AND

methodsThe adjuvant potential of naringenin (N), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (TMF), cilicione-a (Cil), rosmarinic acid (Rs), rosmarinic acid methyl ester (MRs), and fulgidic acid was evaluated by determining the minimum inhibitory concentrations (MICs) of selected antibiotics in presence of sub-inhibitory concentrations of these compounds. The assays were performed against ten bacterial strains using the twofold broth microdilution method. Test samples were prepared in 96-well microtiter plates, incubated at 37 °C for 18 h, and dimethyl sulfoxide was used as the solvent control.

resultsN, Rs, and MRs reduced the MIC value of GEN from 0.78 µM to 0.097 µM against the drug-resistant DISCUSSION AND

conclusionsThese findings highlight the potential of such combinations to enhance antibiotic efficacy, lower the required dosages, and contribute to mitigating the emergence of antimicrobial resistance.

Indexed as

Adjuvants, PharmaceuticAnti-Bacterial AgentsGram-Negative BacteriaGram-Positive BacteriaPlant ExtractsSaturejaDrug SynergismMicrobial Sensitivity TestsAdjuvants, PharmaceuticAnti-Bacterial AgentsPlant Extractsadjuvantcilicione-acombinations with antibioticsFlavonesfulgidic acidnaringeninrosmarinic acid

Identifiers

PMID41097811
PMCPMC12532358

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.