Evidence map›Paper›PMID 41097551›Full record

ArticleFoods (Basel, Switzerland)2025

Valorization of Tomato Leaves: Optimization of Eco-Friendly Phenolic Extraction and Assessment of Biological Activities.

Layan Helmi, Suhair Sunoqrot, Samah Abusulieh, Rawan Huwaitat, Espérance Debs, Salma Khazaal, Mohammad H El-Dakdouki, Nicolas Louka, Nada El Darra

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Layan HelmiDepartment of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut 1107 2809, Lebanon.
Suhair SunoqrotDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0002-7817-1390
Samah AbusuliehDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.
Rawan HuwaitatDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0003-4257-7310
Espérance DebsDepartment of Biology, Faculty of Arts and Sciences, University of Balamand, Tripoli 1300, Lebanon.ORCID 0000-0003-1637-7518
Salma KhazaalDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, Tarik El Jedidah, Riad EL Solh, Beirut 1107 2809, Lebanon.
Mohammad H El-DakdoukiDepartment of Chemistry, Faculty of Science, Beirut Arab University, Riad El Solh, Beirut 1107 2809, Lebanon.ORCID 0000-0003-0679-2267
Nicolas LoukaCentre d'Analyses et de Recherche, Unité de Recherche Technologies et Valorisation Agro-Alimentaire, Faculté des Sciences, Université Saint-Joseph de Beyrouth, Mar Roukos, Dekwaneh, Riad El Solh, Beirut 1107 2050, Lebanon.ORCID 0000-0001-5645-5926
Nada El DarraDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, Tarik El Jedidah, Riad EL Solh, Beirut 1107 2809, Lebanon.ORCID 0000-0002-6568-5536

Funding

Arab German Young Academy of Sciences and Humanities grant 01DL20003.
6 · The paper itself

Abstract

Tomato leaves, typically discarded during harvest, are a rich yet underutilized source of bioactive compounds. This study aimed to valorize tomato leaves by optimizing the extraction of their phenolic compounds using a water-based method and response surface methodology. The optimal conditions, notably heating a mixture of 1:50 solid-to-liquid ratio at 71 °C for 29 min, yielded the most total phenolic content and antioxidant activity. The biological activities of the lyophilized tomato leaf extract (TLE) were then assessed. TLE showed dose-dependent antimicrobial activity against

Indexed as

agricultural waste managementanti-canceranti-inflammatoryantioxidantLC-MSpolyphenolstomato leaves

Identifiers

PMID41097551
PMCPMC12523334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.