Evidence map›Paper›PMID 41097419›Full record

ReviewMolecules (Basel, Switzerland)2025

Methods for Conjugating Antibodies with Quantum Dots.

Pavel Sokolov, Alexander Knysh, Irina Kriukova, Pavel Samokhvalov, Yury V Kistenev

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Bandgap-Engineered PtAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pavel SokolovLaboratory of Optical Quantum Sensors, Life Improvement by Future Technologies (LIFT) Center, Skolkovo, 143025 Moscow, Russia.ORCID 0000-0001-5321-3753
Alexander KnyshLaboratory of Optical Quantum Sensors, Life Improvement by Future Technologies (LIFT) Center, Skolkovo, 143025 Moscow, Russia.ORCID 0009-0006-6219-7568
Irina KriukovaLaboratory of Optical Quantum Sensors, Life Improvement by Future Technologies (LIFT) Center, Skolkovo, 143025 Moscow, Russia.ORCID 0000-0003-4551-2870
Pavel SamokhvalovLaboratory of Optical Quantum Sensors, Life Improvement by Future Technologies (LIFT) Center, Skolkovo, 143025 Moscow, Russia.ORCID 0000-0002-2878-8376
Yury V KistenevLaboratory of Laser Molecular Imaging and Machine Learning, National Research Tomsk State University, 36 Lenin Av., 634050 Tomsk, Russia.ORCID 0000-0001-5760-1462

Funding

Russian Science Foundation (RSF) 22-75-10103-ПRussian Science Foundation (RSF) 23-75-30016
6 · The paper itself

Abstract

Nanomaterials are increasingly used in the development of detection systems for various disease biomarkers as tools for reliable early diagnosis, which is a key factor in reducing mortality and increasing treatment effectiveness. The use of quantum dot-antibody conjugates allows for optical detection of various disease markers in biological fluids, tissues, and individual cells with high sensitivity and specificity. The sensitivity and specificity of detection are determined not only by the outstanding optical properties of fluorescent quantum dots but also by the type of antibodies used for binding target analytes and the methods of their conjugation with quantum dots. This review deals with methods of site-specific and site-nonspecific conjugation of quantum dots with antibodies, including full-length and single-domain antibodies, as well as antibody fragments, with a special focus on their structural features and active moieties used for binding to their targets. The review includes examples of successful applications of quantum dot-conjugated antibodies in diagnosis, environment monitoring, and food safety assessment. We also discuss the prospects of further research in this field, including new conjugation methods and issues related to the stability and specificity of probes. The review provides a comprehensive analysis of the current methods and achievements in antibody conjugation from the viewpoint of subsequent analyte detection, highlighting the importance of further research for improving the existing technologies.

Indexed as

AntibodiesImmunoconjugatesQuantum DotsAnimalsHumansAntibodiesImmunoconjugatesantibodyconjugatequantum dotsite-nonspecificsite-specific

Identifiers

PMID41097419
PMCPMC12526299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.