ArticleMolecules (Basel, Switzerland)2025
Optimization of the Macrocyclic Tetrapeptide [D-Trp]CJ-15,208 to Prevent Stress-Induced Relapse of Cocaine-Seeking Behavior.
Jane V Aldrich, Dmitry Y Yakovlev, Jeremy S Coleman, Sanjeewa N Senadheera, Heather M Stacy, Shainnel O Eans, Brian I Knapp, Jean M Bidlack, Jay P McLaughlin
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Jane V AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-7954-9850 Dmitry Y YakovlevDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Jeremy S ColemanDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-1005-3355 Sanjeewa N SenadheeraDepartment of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0003-0798-1721 Heather M StacyDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Shainnel O EansDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0009-0004-4995-1410 Brian I KnappDepartment of Pharmacology and Physiology, College of Medicine, University of Rochester, Rochester, NY 14642, USA.
Jean M BidlackDepartment of Pharmacology and Physiology, College of Medicine, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0002-4305-5111 Jay P McLaughlinDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-9851-9342 Funding
Cyclic Peptides to Treat Cocaine Use DisorderUH3NS132600 · NINDS · UNIVERSITY OF FLORIDA · PI ALDRICH, JANE V, BIDLACK, JEAN M · 2024 to 2024
$982kCyclic Peptides to Treat Cocaine Use DisorderUG3NS132600 · NINDS · UNIVERSITY OF FLORIDA · PI ALDRICH, JANE V, BIDLACK, JEAN M · 2023 to 2023
$945kNINDS NIH HHS UG3 NS132600NINDS NIH HHS UH3 NS132600
6 · The paper itselfAbstract
Kappa opioid receptor (KOR) antagonists may have therapeutic potential to prevent stress-induced relapse in abstinent individuals with cocaine use disorder (CUD). The macrocyclic peptide [D-Trp]CJ-15,208 (
Indexed as
CocaineCocaine-Related DisordersDrug-Seeking BehaviorPeptides, CyclicStress, PsychologicalAnimalsBehavior, AnimalDisease Models, AnimalMaleMiceReceptors, Opioid, kappaRecurrenceCJ 15,208CocainePeptides, CyclicReceptors, Opioid, kappabrain–penetrant peptidescocaine abuse[D-Trp]CJ-15,208kappa opioid receptor antagonistorally active peptidesstress-induced reinstatement
Identifiers
PMID41097413
PMCPMC12526156
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