Discovery of Primaquine-Indole Carboxamides with Cancer-Cell-Selective Antiproliferative Activity.

Benjamin H Peer, Jeremiah O Olugbami, Dipak T Walunj, Adegboyega K Oyelere

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Lactobionic Acid as a Biocompatibility Switch: Physicochemical and Biological Characterization of Copper(II)-Primaquine Complexes.Bioinorganic chemistry and applications · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin H PeerSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA.ORCID 0009-0002-0745-0752

Jeremiah O OlugbamiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA.ORCID 0000-0002-8287-2499

Dipak T WalunjSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA.ORCID 0009-0004-4563-7985

Adegboyega K OyelereSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA.ORCID 0000-0002-2248-9551

Funding

Development of Novel Targeted Therapeutic Agents for Castration Resistant Prostate CancerR01CA266013 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Chendil Damodaran, Adegboyega Oyelere · 2022 to 2026

$2.7M

Reposition and Optimization of Deferiprone for Breast Cancer TherapyR01CA252720 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI OYELERE, ADEGBOYEGA · 2021 to 2025

$2.4M

NCI NIH HHS R01 CA252720NCI NIH HHS R01 CA266013United States National Institute of Health R01CA252720 and R01CA266013

6 · The paper itself

Abstract

Indole carboxylic acids are endogenous tryptophan metabolites that have demonstrated a variety of bioactivities, including anticancer effects. Specifically, indole acetic acid (IAA) elicits anticancer activity when combined with ultraviolet B or reactive oxygen species (ROS) generators. Primaquine (PQ) is an approved drug which elicits antimalarial activity through ROS generation. We investigated the effects of ICA, IAA, PQ, their combination and PQ-indole carboxamide conjugates on the viability of selected cancer cell lines. We identified PQ-indole carboxamide

Indexed as

Antineoplastic AgentsIndolesNeoplasmsPrimaquineCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHumansReactive Oxygen SpeciesAntineoplastic AgentsIndolesPrimaquineReactive Oxygen Speciesandrogen receptorcancercell cycle progressioncytotoxicityindole carboxylic acidsprimaquinereactive oxygen species

Identifiers

PMID41097408

DOI10.3390/molecules30193988

PMCPMC12526250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.