Inhibitory Effects of Bisphenol Z on 11β-Hydroxysteroid Dehydrogenase 1 and In Silico Molecular Docking Analysis.

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Tomasz TuzimskiDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-3729-3196

Mateusz SugajskiDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Torun, Poland.

Funding

Medical University of Lublin DS 50 (project manager Tomasz Tuzimski)

6 · The paper itself

Abstract

Bisphenol A (BPA) is classified as an endocrine disruptor that mainly mimics the effects of estrogen and disrupts the synthesis of male androgens. Due to the toxicity of BPA, some new analogs, such as bisphenol BPB, BPC, BPF, PBH, and BPZ, were introduced into the market. The goal of this research was to demonstrate the applicability of kinetic analysis, in particular, Lineweaver-Burk plots, in assessing the impact of bisphenol Z on enzymatic activity. This study aimed to characterize the inhibitory effects of BPZ on 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity in the transformation of 11-dehydrocorticosterone (DHC) to corticosterone (CORT). During the determination of the enzymatic reaction product, chromatographic analysis conditions were optimized using gradient elution and an Acquity UPLC BEH C18 chromatographic column. The retention time of the assayed corticosterone was approximately 2 min. Also described and compared were graphical methods of analysis and data interpretation, such as Lineweaver-Burk, Eadie-Hofstee, and Hanes-Woolf plots. The experiments demonstrated that bisphenol Z is a mixed 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor, responsible for catalyzing the conversion of 11-dehydrocorticosterone (DHC) to corticosterone (CORT). This relationship was confirmed by analyzing Lineweaver-Burk plots, which showed an increase in apparent

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1Benzhydryl CompoundsEnzyme InhibitorsMolecular Docking SimulationPhenolsBisphenol A CompoundsCorticosteroneEndocrine DisruptorsHumansKinetics11-beta-Hydroxysteroid Dehydrogenase Type 111-dehydrocorticosteroneBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCorticosteroneEndocrine DisruptorsEnzyme InhibitorsPhenols11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)bisphenol Z (BPZ)corticosterone (CORT)Eadie-Hofstee plotsHanes-Woolf plotskinetic analysisLineweaver-Burk plotsmolecular docking

Identifiers

PMID41097361

DOI10.3390/molecules30193941

PMCPMC12525740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.