Evidence map›Paper›PMID 41097334›Full record

ArticleMolecules (Basel, Switzerland)2025

Tiliroside Suppresses Uric Acid Production in Hepatocytes and Attenuates Purine-Induced Hyperuricemia in Male ICR Mice.

Shin-Ichi Adachi, Shinji Kondo, Yusuke Sato, Fumiaki Yoshizawa, Kazumi Yagasaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shin-Ichi AdachiFaculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara 582-0026, Osaka, Japan.
Shinji KondoAlliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Ibaraki, Japan.ORCID 0000-0002-9097-6394
Yusuke SatoSchool of Agriculture, Tokai University, Mashiki 861-2205, Kumamoto, Japan.
Fumiaki YoshizawaSchool of Agriculture, Utsunomiya University, Utsunomiya 321-8505, Tochigi, Japan.ORCID 0000-0001-8799-7701
Kazumi YagasakiUnited Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu 183-8509, Tokyo, Japan.ORCID 0000-0002-9494-9887

Funding

Japan Society for the Promotion of Science JP16K16273Japan Society for the Promotion of Science JP22K05503
6 · The paper itself

Abstract

Tiliroside (kaempferol-3-O-(6''-p-coumaroyl)-glucoside), a flavonoid glycoside found in rose hips and berries, has been reported to possess various bioactivities. This study aimed to evaluate its antihyperuricemic potential by assessing direct xanthine oxidase (XO) inhibitory activity, suppression of uric acid (UA) production in AML12 hepatocytes, and efficacy in male ICR mice with purine nucleotide-induced hyperuricemia. XO inhibition was evaluated using a UV absorbance-based assay, and UA production was measured in hepatocytes stimulated with UA precursors. Mice were orally administered tiliroside for three days prior to purine nucleotide injection. Although tiliroside exhibited weak XO inhibition (IC

Indexed as

FlavonoidsHepatocytesHyperuricemiaPurinesUric AcidAnimalsLiverMaleMiceMice, Inbred ICROrganic Anion TransportersXanthine OxidaseFlavonoidsOrganic Anion TransportersPurinestilirosideUric AcidXanthine OxidaseAML12 hepatocytesgouthyperuricemiapurine bodytilirosideuric acidxanthine oxidase

Identifiers

PMID41097334
PMCPMC12526004

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.