ArticleMolecules (Basel, Switzerland)2025
1,2,4-Thiadiazolidin-3,5-Diones as Inhibitors of Cysteine Proteases.
Maria Aparecida Juliano, Marco Persico, Beatrice Severino, Giuseppe Tumbarello, Debora Okamoto, Karolina Rosa Fernandes, Gabriel Trigo, Aparecida Sadae Tanaka, José Thalles Lacerda, Oleh Tkachuck and 9 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Maria Aparecida JulianoDepartment of Biophysics, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.
Marco PersicoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0003-0010-0338 Beatrice SeverinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0002-3887-8869 Giuseppe TumbarelloDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0009-0004-9702-2157 Debora OkamotoDepartment of Pharmaceutical Sciences, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.
Karolina Rosa FernandesDepartment of Biophysics, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.
Gabriel TrigoDepartment of Biophysics, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.ORCID 0009-0004-4572-2960 Aparecida Sadae TanakaDepartment of Biochemistry, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.ORCID 0000-0001-9407-805X José Thalles LacerdaDepartment of Biophysics, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.ORCID 0000-0003-4588-7197 Oleh TkachuckDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0009-0003-5349-1405 Angela CorvinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0002-0617-156X Ferdinando FiorinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0001-7357-5751 Antonia ScognamiglioDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0002-4282-2788 Francesco FrecenteseDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0001-8821-2937 Vincenzo SantagadaDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.
Stefania VertuccioDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0009-0004-0542-132X Giuseppe CaliendoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.
Luiz JulianoDepartment of Biophysics, Escola Paulista Medicina, Universidade Federal São Paulo, Rua Tres de Maio, 100, São Paulo 04044-020, SP, Brazil.ORCID 0000-0002-5589-2822 Caterina FattorussoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano, 49, 80131 Napoli, Italy.ORCID 0000-0003-3330-4281 Funding
Program Capes-PrInt 88881.311044/2018-00 - FAPESP # 2018/13588-0
6 · The paper itselfAbstract
A focused library of 1,2,4-thiadiazolidin-3,5-diones (
Indexed as
Antiviral AgentsCoronavirus 3C ProteasesCysteine ProteasesCysteine Proteinase InhibitorsSARS-CoV-2ThiadiazolesCatalytic DomainHumansMolecular Docking SimulationPapainStructure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine ProteasesCysteine Proteinase InhibitorsPapainThiadiazoles1,2,4-thiadiazolidin-3,5-diones3CLproCathepsin Lcysteine proteases inhibitorsmolecular modelingPapainPLproSARS-CoV-2
Identifiers
PMID41097318
PMCPMC12526058
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390