Diastereoselective Reformatsky Reaction Mediated by Dichlorocyclopentadienyltitanium(III).

Josefa L López-Martínez, Irene Torres-García, Manuel Muñoz-Dorado, Miriam Álvarez-Corral, Ignacio Rodríguez-García

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Josefa L López-MartínezOrganic Chemistry, University of Almería, CIAIMBITAL, 04120 Almería, Spain.ORCID 0000-0003-2598-1573

Irene Torres-GarcíaOrganic Chemistry, University of Almería, CIAIMBITAL, 04120 Almería, Spain.ORCID 0000-0003-0967-4311

Manuel Muñoz-DoradoOrganic Chemistry, University of Almería, CIAIMBITAL, 04120 Almería, Spain.ORCID 0000-0002-2679-270X

Miriam Álvarez-CorralOrganic Chemistry, University of Almería, CIAIMBITAL, 04120 Almería, Spain.ORCID 0000-0002-4300-4680

Ignacio Rodríguez-GarcíaOrganic Chemistry, University of Almería, CIAIMBITAL, 04120 Almería, Spain.ORCID 0000-0002-2985-8567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Reformatsky reaction, first reported in 1887, has long been recognized as a fundamental method for carbon-carbon bond construction due to its mild conditions and functional group tolerance. Over the past few decades, this transformation has undergone a notable revival, with modern catalytic variants addressing limitations of stoichiometric protocols and expanding its role in complex molecule synthesis. Yet, despite its versatility, achieving stereoselective control remains a longstanding challenge. Herein we report the use of dichlorocyclopentadienyltitanium(III) (CpTiCl

Indexed as

CpTiCl2cross-coupling reactiondiastereoselectivityReformatsky reactionβ-hydroxyesters

Identifiers

PMID41097314

DOI10.3390/molecules30193893

PMCPMC12525768

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