Evidence map›Paper›PMID 41097279›Full record

ArticleMolecules (Basel, Switzerland)2025

Ultrasound-Assisted Pressurized Fluid Extraction of Antioxidant and Anticancer Molecules from a Mangaba, Cambuí and Red Propolis Blend.

Diego S de Oliveira, Marília R Oliveira, Glenda A da Silva, Cristiane B Corrêa, Ana Veruska C da Silva, Jhonattas de C Carregosa, Alberto Wisniewski, Maria Beatriz P P Oliveira, Claudio Dariva, Klebson S Santos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diego S de OliveiraCenter for Study on Colloidal Systems (NUESC), Institute of Research and Technology and (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju 49032-490, SE, Brazil.ORCID 0009-0006-5621-8270
Marília R OliveiraCenter for Study on Colloidal Systems (NUESC), Institute of Research and Technology and (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju 49032-490, SE, Brazil.ORCID 0000-0001-9396-9846
Glenda A da SilvaDepartment of Morphology, Federal University of Sergipe (UFS), São Cristóvão 49100-000, SE, Brazil.ORCID 0000-0002-2866-2052
Cristiane B CorrêaDepartment of Morphology, Federal University of Sergipe (UFS), São Cristóvão 49100-000, SE, Brazil.ORCID 0000-0001-8954-6285
Ana Veruska C da SilvaEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Av. Beira-Mar, 3.250, Aracaju 49025-040, SE, Brazil.ORCID 0000-0002-4177-9335
Jhonattas de C CarregosaCenter for Study on Colloidal Systems (NUESC), Institute of Research and Technology and (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju 49032-490, SE, Brazil.ORCID 0000-0002-9789-4551
Alberto WisniewskiPetroleum and Energy from Biomass Research Group (PEB), Department of Chemistry, Federal University of Sergipe (UFS), São Cristóvão 49100-000, SE, Brazil.ORCID 0000-0001-6815-0265
Maria Beatriz P P OliveiraREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira, 228, 4050-313 Porto, Portugal.ORCID 0000-0002-6767-6596
Claudio DarivaCenter for Study on Colloidal Systems (NUESC), Institute of Research and Technology and (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju 49032-490, SE, Brazil.ORCID 0000-0002-5239-9039
Klebson S SantosCenter for Study on Colloidal Systems (NUESC), Institute of Research and Technology and (ITP), Tiradentes University (UNIT), Av. Murilo Dantas, 300, Aracaju 49032-490, SE, Brazil.ORCID 0000-0001-5772-9634

Funding

CNPq CNPq/MCTI Call No. 10/2023 (Process No. 407015/2023)
6 · The paper itself

Abstract

This study explored the antioxidant and anticancer potential of extracts obtained from the mangaba, cambuí, and red propolis blend. The extracts were obtained using ultrasound-assisted pressurized fluid extraction (UAPFE) at 50 bar, 60 °C, and a flow rate of 2 mL/min. Both sequential extraction with solvents of increasing polarity (propane followed by ethanol/water) and one-step extraction were employed for 30 min. Extracts were characterized by ultra-high-resolution mass spectrometry, total phenolic content, antioxidant activity (via DPPH and FRAP assays), and cytotoxicity using the sulforhodamine B colorimetric method. Among the tested conditions, the sequential extraction with ethanol/water (UAPFE-SE) yielded 16.2 ± 3.0% (overall extraction yield), with high phenolic content (24.1 ± 0.4 µg/mg). Mass spectrometry revealed the presence of antiproliferative phenolics. The UAPFE-SE extract demonstrated moderate antioxidant activity, with FRAP values of 394.0 ± 6.0 µg Fe

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicAntioxidantsPlant ExtractsPropolisCell Line, TumorCell ProliferationHumansPhenolsSolventsUltrasonic WavesAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntioxidantsPhenolsPlant ExtractsPropolisSolventsbioactive compoundsgreen solventsHancornia speciosalung cancerMyrciaria floribundapressurized liquid extractionsonication

Identifiers

PMID41097279
PMCPMC12525853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.