Evidence map›Paper›PMID 41097256›Full record

ArticleNutrients2025

Gastrointestinal Survivability of a BSH-Positive

Amanda Vaccalluzzo, Gianluigi Agolino, Alessandra Pino, Marianna Cristofolini, Davide Tagliazucchi, Alice Cattivelli, Cinzia Caggia, Lisa Solieri, Cinzia Lucia Randazzo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amanda VaccalluzzoDepartment of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4902-1799
Gianluigi AgolinoDepartment of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.ORCID 0009-0005-1610-8811
Alessandra PinoDepartment of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8246-106X
Marianna CristofoliniDepartment of Life Science, University of Modena and Reggio Emilia, 42122 Reggio Emilia, Italy.
Davide TagliazucchiDepartment of Life Science, University of Modena and Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0002-6462-9305
Alice CattivelliDepartment of Life Science, University of Modena and Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0002-6841-3608
Cinzia CaggiaDepartment of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-2688-9536
Lisa SolieriDepartment of Life Science, University of Modena and Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0003-3546-6903
Cinzia Lucia RandazzoDepartment of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1243-5357

Funding

University of Modena and Reggio Emilia CN_00000033
6 · The paper itself

Abstract

backgroundBile salt hydrolase (BSH) is a key probiotic trait, as it facilitates both host metabolism and bacterial survival into the gastrointestinal tract (GIT), through bile acid (BA) deconjugation, keeping intestinal homeostasis.

objectivesThe present study aims to investigate the viability of the

methodsGastric, small intestinal and colonic fractions were monitored and a fecal slurry from a healthy donor was inoculated into the colonic compartment to establish the intestinal microbiota. Samples were collected at the end of stomach, duodenum, jejunum, ileum phases, and colon after 0, 16 and 24 h. Strain survival was assessed by culturing method, and

resultsGood survivability of the VB4 strain in the upper GIT was revealed. Furthermore, VB4-inculated sample showed sustained expression of

conclusionsThese findings highlight the survivability of

Indexed as

AmidohydrolasesBile Acids and SaltsGastrointestinal MicrobiomeGastrointestinal TractLacticaseibacillus rhamnosusProbioticsFecesHumansMicrobial ViabilityModels, BiologicalAmidohydrolasesBile Acids and Saltscholoylglycine hydrolasebile acidsbile salt hydrolasebsh gene expressiondynamic simulatormetabolomic profilestrain survivability

Identifiers

PMID41097256
PMCPMC12526281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.