Evidence map›Paper›PMID 41097252›Full record

ArticleNutrients2025

Effects of Food Preferences and Supplement Intake During Pregnancy on the Cleft Lip and Palate Incidence: The Japan Environment and Children's Study.

Kumiko Fujiwara, Hazuki Tamada, Hideto Imura, Taro Matsuki, Hiroo Furukawa, Nagato Natsume, Yasuyuki Yamada, Takeshi Ebara, Michihiro Kamijima, The Japan Environment And Children's Study Jecs Group

Abstract read
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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kumiko FujiwaraOral and Maxillofacial Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki 5698686, Osaka, Japan.ORCID 0000-0001-9158-4141
Hazuki TamadaDepartment of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan.
Hideto ImuraOral and Maxillofacial Surgery, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Taro MatsukiDepartment of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan.
Hiroo FurukawaCleft Lip and Palate Center, Aichi Gakuin University Dental Hospital, Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, Aichi, Japan.
Nagato NatsumeCleft Lip and Palate Center, Aichi Gakuin University Dental Hospital, Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, Aichi, Japan.ORCID 0000-0001-7943-2284
Yasuyuki YamadaDepartment of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan.
Takeshi EbaraDepartment of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan.ORCID 0000-0003-3342-1058
Michihiro KamijimaDepartment of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan.ORCID 0000-0003-0670-8790
The Japan Environment And Children's Study Jecs Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCleft lip and/or palate (CL/P) is a high-frequency congenital disease. Besides genetic background, maternal environmental factors may be involved in its incidence. We examined the effects of unbalanced diets and the intake of dietary supplements during pregnancy on the incidence of non-syndromic CL/P (NSCLP) via a case-control study design with multiple case groups. The case group diagnosed with NSCLP included 281 patients, 217 from the Japan Environment and Children's Study (JECS) data and 64 from the Aichi Gakuin University Hospital from 2011 to 2014. The control group comprised 87,477 (excluding cases with multiple births, chromosomal abnormalities, or complications) of the 104,062 fetal records registered in JECS.

resultsThe results revealed a significantly increased risk of NSCLP (aOR 2.86, 95% CI 1.63-5.00) in mothers who avoided two or more food items out of the investigated five, i.e., milk and dairy products, eggs, soy, fish, and beef. No association was identified in mothers who avoided one food.

conclusionsProviding nutritional support when multiple foods are avoided in daily food habits may be effective in reducing the occurrence of NSCLP.

Indexed as

Cleft LipCleft PalateDietary SupplementsFood PreferencesMaternal Nutritional Physiological PhenomenaAdultCase-Control StudiesDietFemaleHumansIncidenceJapanMalePregnancyRisk Factorsfood preferenceJECSnon-syndromic cleft lip and/or palatesupplement

Identifiers

PMID41097252
PMCPMC12526071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.