Evidence map›Paper›PMID 41097182›Full record

ReviewNutrients2025

Antimicrobial and Anti-Inflammatory Bioactive Peptides: Their Role in Potential Therapeutic Applications for Periodontitis-A Narrative Review.

Federica Tonolo, Renata Cristina Lima Silva, Mary Bortoluzzi, Raquel Mantuaneli Scarel-Caminaga, Fabio Vianello

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Federica TonoloDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, PD, Italy.ORCID 0000-0002-7780-8994
Renata Cristina Lima SilvaDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara, São Paulo State University-UNESP, Araraquara 14801-903, SP, Brazil.
Mary BortoluzziDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, PD, Italy.ORCID 0009-0008-4573-6931
Raquel Mantuaneli Scarel-CaminagaDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry at Araraquara, São Paulo State University-UNESP, Araraquara 14801-903, SP, Brazil.ORCID 0000-0001-5068-0268
Fabio VianelloDepartment of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Legnaro, PD, Italy.ORCID 0000-0002-4874-7205

Funding

CAPES-PrInt (Institutional Internationalization Program) 63/2023CNPq financement 306433/2023-0FAPESP (São Paulo Research Foundation) 2022/06607-3PNRR project: iNEST- Interconnected Nord-Est Innovation ECS00000043PNRR Young Researchers Project CirculaR EConomy to enhance the sustainabilitY of agri-food Chain: An innovative approach to transform food wastE into functionaL foods
6 · The paper itself

Abstract

Bioactive peptides have garnered increasing interest in recent years due to their potential applications in the medical field, for example, as promising adjuvant therapeutic agents to modulate the host immune response and counteract microbial dysbiosis in chronic pathologies. Primarily derived from protein hydrolysates of food waste, these components exhibit beneficial properties, such as anti-inflammatory, antimicrobial, antioxidant, and antidiabetic effects. This narrative review focuses on bioactive peptides with antimicrobial and anti-inflammatory properties, highlighting their mechanisms of action, sources, and therapeutic potential in the context of chronic conditions, particularly periodontal disease, especially when comorbidities are present (i.e., type 2 diabetes mellitus). The mechanisms of action and sources, as well as preclinical and clinical studies evaluating bioactive peptides efficacy, are discussed. Further research is warranted to establish their clinical viability and integration into conventional therapeutic strategies.

Indexed as

Anti-Infective AgentsAnti-Inflammatory AgentsAntimicrobial PeptidesPeptidesPeriodontitisAnimalsHumansAnti-Infective AgentsAnti-Inflammatory AgentsAntimicrobial PeptidesPeptidesanti-inflammatoryantimicrobialbioactive peptideschronic diseasesdiabetesperiodontitis

Identifiers

PMID41097182
PMCPMC12526372

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.