Evidence map›Paper›PMID 41097168›Full record

ArticleNutrients2025

Medical Nutrition Therapy Adherence and Lifestyle in Stage 5 CKD: Challenges and Insights.

Patrizia Palumbo, Gaetano Alfano, Francesca Cavani, Rossella Giannini, Roberto Angelo Pulizzi, Silvia Gabriele, Niccolò Morisi, Floriana Cannito, Renata Menozzi, Gabriele Donati

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrizia PalumboDivision of Metabolic Diseases and Clinical Nutrition, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0001-5058-2350
Gaetano AlfanoNephrology, Dialysis and Kidney Transplant Unit, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0003-0591-8622
Francesca CavaniDivision of Metabolic Diseases and Clinical Nutrition, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.
Rossella GianniniDivision of Metabolic Diseases and Clinical Nutrition, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.
Roberto Angelo PulizziNephrology, Dialysis and Kidney Transplant Unit, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.
Silvia GabrieleDivision of Metabolic Diseases and Clinical Nutrition, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.
Niccolò MorisiNephrology, Dialysis and Kidney Transplant Unit, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.ORCID 0009-0000-0753-3326
Floriana CannitoSurgical, Medical, Dental and Morphological Sciences Department (CHIMOMO), University of Modena and Reggio Emilia, 41125 Modena, Italy.
Renata MenozziDivision of Metabolic Diseases and Clinical Nutrition, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.
Gabriele DonatiNephrology, Dialysis and Kidney Transplant Unit, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0001-8549-1221

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdherence to Medical Nutrition Therapy (MNT) is a key determinant of therapy success, particularly in chronic diseases like chronic kidney disease (CKD). MNT in CKD requires significant changes in patient's dietary habits, which can affect long-term adherence. This study aims to evaluate the adherence to MNT in stage 5 CKD patients undergoing conservative kidney management (CKM), identifying potential challenges and strengths of nutritional intervention.

methodsWe enrolled in 94 stage 5 CKD patients undergoing CKM at the University Hospital of Modena, Italy. We collect clinical data from medical and nutrition records. The inclusion criteria comprised patients of all genders, ages, and ethnicity with stage 5 chronic kidney disease (CKD), in pre-dialysis, enrolled in the nephrology and dietetics program, who had access to 24-h urine tests, anthropometric measurements, and dietary history records. Exclusion criteria included patients with CKD stages lower than 5, those who had not undergone at least one nutritional assessment, or lacked accessible 24-h urine data. The study utilized medical and dietary records from September 2017 to March 2025. The primary outcome was the assessment of adherence to medical nutrition therapy (MNT), comparing prescribed protein intake with actual intake, estimated from dietary history (DH). Protein intake was compared with normalized protein nitrogen appearance (nPNA) as stated by recent guidelines. Additional factors influencing adherence, such as age, gender, comorbidities, physical activity, and prior dietary interventions, were also evaluated. Anthropometric measurements and biochemical tests were collected, and dietary intake was assessed using a seven-day DH.

resultsData were analyzed using descriptive statistics, linear correlation models, univariate logistic regression,

conclusionsAssessing dietary adherence in CKD remains complex due to inconsistencies between self-reported and biochemical estimates. These findings highlight the need for more objective dietary assessment tools and ongoing, tailored nutritional support. Multifaceted interventions-combining education, personalized planning, regular monitoring, and promotion of physical activity-are recommended to enhance adherence and improve clinical outcomes in this vulnerable population.

Indexed as

Life StyleNutrition TherapyPatient ComplianceRenal Insufficiency, ChronicAgedDietary ProteinsFemaleHumansItalyMaleMiddle AgedNutrition AssessmentDietary Proteinschronic kidney managementCKDdiet adherencemedical nutrition therapy

Identifiers

PMID41097168
PMCPMC12526388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.