Evidence map›Paper›PMID 41097148›Full record

ReviewNutrients2025

Effects of Athletic Nutritional Supplements on the Human Gut Microbiota: A Narrative Review.

Themistoklis Katsimichas, Anastasia Xintarakou, Charalambos Vlachopoulos, Costas Tsioufis, George Lazaros

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Themistoklis KatsimichasFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece.
Anastasia XintarakouFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece.ORCID 0000-0003-0135-8023
Charalambos VlachopoulosFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece.ORCID 0000-0002-9904-3558
Costas TsioufisFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece.
George LazarosFirst Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, V. Sofias 114, 11527 Athens, Greece.ORCID 0000-0003-2802-9617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiota constitutes the microbial ecosystem within the human gut. It consists of trillions of mostly prokaryotic microorganisms living in the gut lumen, which have an active metabolic role in the regulation of many host functions, including vitamin synthesis and energy extraction from indigestible fiber. Host diet is the main driver of gut microbial composition and metabolic output. Athletes and athletic individuals often supplement their diet with legal nutritional supplements to enhance performance, especially at the elite level. This review summarizes and critically comments on key evidence of the effects of the most common athletic nutritional supplements on the human gut microbiota, based on the most recent literature. We cover suggested changes in bacterial diversity or the relative abundance of specific bacterial taxa and effects of nutritional supplementation on bacterial metabolism. We focus on the molecular pathways involved, we discuss contrasting results and inconsistencies, and we note limitations and challenges in the field. We conclude with a summary of evidence, proposals, and future directions.

Indexed as

AthletesDietary SupplementsGastrointestinal MicrobiomeSports Nutritional Physiological PhenomenaAthletic PerformanceHumansantioxidantsathletesbranched-chain amino acidsgut microbiotanutritional supplementsproteinPUFA

Identifiers

PMID41097148
PMCPMC12525813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.