Cinnamaldehyde Inhibits Leptin-Induced MMP-1 by Modulating Leptin Receptor/STAT3 and Blocking RhoA/NF-κB Pathways in Human Intervertebral Disc Stem Cells.

Kuo-Feng Hua, Hsin-Chiao Yu, Hsien-Ta Hsu

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology.Frontiers in immunology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, Ilan 260007, Taiwan.ORCID 0000-0001-8436-8299

Hsin-Chiao YuDivision of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.

Hsien-Ta HsuDivision of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.

Funding

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation TCRD-TPE-112-27

6 · The paper itself

Abstract

Obesity is a recognized risk factor for intervertebral disc (IVD) degeneration, a condition characterized by the progressive loss of extracellular matrix components in the nucleus pulposus. Elevated circulating leptin levels in obese individuals contribute to this degeneration by upregulating matrix metalloproteinase-1 (MMP-1) expression. Targeting MMP-1 expression with low-toxicity natural compounds may provide a promising strategy to prevent or mitigate IVD degeneration. In this study, we examined the effects of cinnamaldehyde (CA), a natural compound derived from

Indexed as

AcroleinIntervertebral DiscIntervertebral Disc DegenerationLeptinObesityCell LineGene Expression RegulationHumansMatrix Metalloproteinase 1NF-kappa BPhosphorylationReceptors, MitogenrhoA GTP-Binding ProteinSignal TransductionSTAT3 Transcription FactorStem CellsAcroleincinnamaldehydeLeptinMatrix Metalloproteinase 1MMP1 protein, humanNF-kappa BReceptors, MitogenrhoA GTP-Binding ProteinRHOA protein, humanSTAT3 protein, humanSTAT3 Transcription Factorcinnamaldehydeintervertebral disc cartilage endplate-derived stem cellsintervertebral disc degenerationleptinmatrix metalloproteinase

Identifiers

PMID41097084

DOI10.3390/ijms26199819

PMCPMC12525311

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.