Evidence map›Paper›PMID 41097071›Full record

ArticleInternational journal of molecular sciences2025

Transthyretin Amyloidosis-One of the Causes of Heart Failure in Patients with Severe Clinical Course of COVID-19.

Zarina Gioeva, Liudmila Mikhaleva, Nikita Gutyrchik, Nikolay Shakhpazyan, Valentina Pechnikova, Konstantin Midiber, Andrej Kontorshchikov, Elizaveta Zentsova, Lev Kakturskij

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zarina GioevaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0002-5456-8692
Liudmila MikhalevaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0003-2052-914X
Nikita GutyrchikAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0002-2352-278X
Nikolay ShakhpazyanAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0003-3386-7746
Valentina PechnikovaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0001-5896-4556
Konstantin MidiberAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0002-1426-968X
Andrej KontorshchikovAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Elizaveta ZentsovaAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.
Lev KakturskijAvtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution, "Petrovsky National Research Centre of Surgery", 117418 Moscow, Russia.ORCID 0000-0001-7896-2080

Funding

Ministry of Education and Science of the Russian Federation No 123030700032-9Russian Science Foundation No 23-15-00138
6 · The paper itself

Abstract

Wild-type transthyretin amyloidosis is an underdiagnosed condition that significantly contributes to mortality in the elderly population. This histopathological study describes autopsy findings in patients with severe clinical course of COVID-19 and ATTR not identified during life. Autopsy findings in the myocardium were analyzed in 19 patients with pre-existing ATTR who died from severe COVID-19. RT PCR was used for pre- and post-mortem detection of SARS-CoV-2 RNA. Immunohistochemical typing was performed with a broad panel of antibodies against different amyloid types. Autopsy specimens from the myocardium and lungs were positive for SARS-CoV-2 RNA in 10 (53%) cases. Microscopic examination of the myocardium revealed focal cardiosclerosis and cardiomyocyte dissociation in 15 (68%) cases, hypertrophy and atrophy of cardiomyocytes in 17 (77%) and 7 (32%), respectively, and myocarditis in 4 (18%) cases. Immunohistochemical analysis determined ATTR amyloidosis in all cases. In patients with rapidly progressive heart failure, the postmortem examination revealed multiple sites of interstitial amyloid deposits and focal cardiosclerosis in the myocardium. Pre-existing cardiac amyloidosis contributes to the aggressive clinical course of COVID-19. Coupled with the toxic effect of the SARS-CoV-2 virus on the myocardium, the disease may lead to progressive heart failure and poor outcomes.

Indexed as

Amyloid Neuropathies, FamilialCOVID-19Heart FailureAgedAged, 80 and overAutopsyFemaleHumansMaleMiddle AgedMyocardiumPrealbuminSARS-CoV-2PrealbuminamyloidosiscardiosclerosisCOVID-19heart failureimmunohistochemistrytransthyretin amyloidosis

Identifiers

PMID41097071
PMCPMC12524381

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