Evidence map›Paper›PMID 41097052›Full record

ArticleInternational journal of molecular sciences2025

Cobalt(II) Complexes of 4'-Bromo-Fenamic Acid: Antioxidant Properties, Antibacterial Activity, and Interaction with DNA and Albumins.

Georgios Malis, Christina N Banti, Alexia Tialiou, Michael R Reithofer, Antonios G Hatzidimitriou, Sotiris K Hadjikakou, Konstantina C Fylaktakidou, George Psomas

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Georgios MalisLaboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-9462-6148
Christina N BantiDepartment of Chemistry, University of Ioannina, GR-45110 Ioannina, Greece.ORCID 0000-0001-6727-2711
Alexia TialiouInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.ORCID 0000-0002-3670-8305
Michael R ReithoferInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.ORCID 0000-0002-6328-1896
Antonios G HatzidimitriouLaboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0001-6237-126X
Sotiris K HadjikakouDepartment of Chemistry, University of Ioannina, GR-45110 Ioannina, Greece.ORCID 0000-0001-9556-6266
Konstantina C FylaktakidouLaboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-2186-2617
George PsomasLaboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-5879-7265

Funding

Hellenic Foundation for Research and Innovation 5708
6 · The paper itself

Abstract

The reaction of 4'-bromo-fenamic acid, a bromo-derivative of fenamic acid (the scaffold of the fenamate non-steroidal anti-inflammatory drugs), with Co(II) in the absence or presence of various nitrogen-donor ligands yielded nine novel, neutral mononuclear Co(II) complexes. These complexes were characterized by physicochemical and spectroscopic techniques and single-crystal X-ray crystallography. The biological evaluation of the compounds focused on their antioxidant and antimicrobial efficacy, as well as their interaction with calf-thymus DNA, pBR322 plasmid DNA (in the absence or presence of diverse irradiations) and serum albumins. The complexes have shown significant antioxidant activity since they can scavenge 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radicals (up to 96.48 ± 0.07%) and reduce H

Indexed as

Anti-Bacterial AgentsAntioxidantsCobaltCoordination ComplexesDNAAnimalsCattleCrystallography, X-RayMicrobial Sensitivity TestsAnti-Bacterial AgentsAntioxidantscalf thymus DNACobaltCoordination ComplexesDNAaffinity for albuminsantimicrobial activityantioxidant activitycobalt(II) complexesDNA bindingfenamatesphotocleavage of DNA

Identifiers

PMID41097052
PMCPMC12524402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.