Evidence map›Paper›PMID 41097041›Full record

ReviewInternational journal of molecular sciences2025

Molecular Landscape of Prostate Cancer Across Age Groups: Impact on Prognosis and Treatment Outcomes.

Magdalena Julita Orzechowska, Andrzej K Bednarek

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Magdalena Julita OrzechowskaDepartment of Molecular Carcinogenesis, Medical University of Łódź, 90-752 Łódź, Poland.ORCID 0000-0002-8301-8059
Andrzej K BednarekDepartment of Molecular Carcinogenesis, Medical University of Łódź, 90-752 Łódź, Poland.ORCID 0000-0002-4570-4154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PC) has long been considered a disease of older men. Still, a significant and concerning rise in diagnoses among younger men has revealed a biologically distinct and more aggressive clinical entity: early-onset prostate cancer (EO-PC). This comprehensive review synthesizes the molecular and clinical evidence to demonstrate that PC is not a single disease, but a collection of distinct entities delineated by patient age. EO-PC is characterized by a strong genetic component, unique fusion events like

Indexed as

Prostatic NeoplasmsAge FactorsAge of OnsetBiomarkers, TumorEpithelial-Mesenchymal TransitionHumansMalePrognosisTreatment OutcomeTumor MicroenvironmentBiomarkers, Tumoragedearly-onset prostate cancerlate-onset prostate cancerneoplasm gradingprecision medicineprostatic neoplasmstumor microenvironment

Identifiers

PMID41097041
PMCPMC12524801

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.