Evidence map›Paper›PMID 41097017›Full record

ArticleInternational journal of molecular sciences2025

Identification of Proteins and MicroRNAs with Prognostic Value for Assisted Reproduction Technology Outcomes in Follicular Fluid of Women with Endometriosis: A Pilot Study.

Ana Catarina Neto, Cláudia Freitas, Ângela Ribeiro, Adriana R Rodrigues, João L Silva-Carvalho, Henrique Almeida, Delminda Neves

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Catarina NetoDepartmento de Biomedicina-Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.ORCID 0000-0002-5292-4390
Cláudia FreitasReproductive Medicine, Obstetrics and Gynaecology Department, Hospital Dr. Nélio Mendonça, Serviço de Saúde da Região Autónoma da Madeira (SESARAM), 9004-514 Funchal, Portugal.
Ângela RibeiroDepartmento de Biomedicina-Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.
Adriana R RodriguesDepartmento de Biomedicina-Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.ORCID 0000-0002-9613-1552
João L Silva-CarvalhoCETI-Centro de Estudo e Tratamento da Infertilidade, 4100-118 Porto, Portugal.
Henrique AlmeidaDepartmento de Biomedicina-Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.ORCID 0000-0002-3036-3211
Delminda NevesDepartmento de Biomedicina-Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal.ORCID 0000-0002-3301-8376

Funding

Merck Serono 2011 Grant for Fertility Innovation (GFI)
6 · The paper itself

Abstract

This study aims to identify molecular markers with prognostic value for biochemical pregnancy in follicular fluid (FF) samples from women with endometriosis after assisted reproductive technology (ART) intervention. Levels of growth differentiation factor-9 (GDF-9), bone morphogenetic protein-15 (BMP-15), and anti-Mullerian hormone (AMH) proteins were semi-quantified by Western blotting and microRNAs 20a_1, 145_1, 320a_1, 125-b-5p, 212-3p, and 199_a by qPCR in FF samples from women submitted to ART with a previous diagnosis of endometriosis (n = 20) or male factor infertility (controls) (n = 44). An increase in GDF-9 and BMP-15 and a decrease in AMH mature protein were observed, as well as an increase in miR20a_1 (

Indexed as

EndometriosisFollicular FluidMicroRNAsReproductive Techniques, AssistedAdultAnti-Mullerian HormoneBiomarkersBone Morphogenetic Protein 15FemaleGrowth Differentiation Factor 9HumansInfertility, FemalePilot ProjectsPregnancyPrognosisROC CurveAnti-Mullerian HormoneBiomarkersBMP15 protein, humanBone Morphogenetic Protein 15GDF9 protein, humanGrowth Differentiation Factor 9MicroRNAsanti-Mullerian hormoneassisted reproductive techniquesbiochemical pregnancybone morphogenetic protein-15endometriosisgrowth differentiation factor-9human follicular fluidinfertilitymicroRNAs

Identifiers

PMID41097017
PMCPMC12525475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.