Evidence map›Paper›PMID 41097008›Full record

ArticleInternational journal of molecular sciences2025

Discovery of Galloyl-Flavonoid Conjugates as SARS-CoV-2 3CL

Nopawit Khamto, Panida Boontawee, Vachira Choommongkol, Kritsada Pruksaphon, Suwicha Patnin, Nuttee Suree, Panchika Prangkio, Puttinan Meepowpan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nopawit KhamtoDepartment of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0003-2321-3722
Panida BoontaweeDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0009-0003-6880-0397
Vachira ChoommongkolDepartment of Chemistry, Faculty of Science, Maejo University, Chiang Mai 50290, Thailand.ORCID 0000-0002-8565-1843
Kritsada PruksaphonCenter of Excellence Research for Melioidosis and Microorganisms (CERMM), Walailak University, Nakhon Si Thammarat 80160, Thailand.ORCID 0000-0002-1391-7163
Suwicha PatninLaboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok 10210, Thailand.ORCID 0000-0002-6272-2944
Nuttee SureeDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-2025-6823
Panchika PrangkioDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-6376-7116
Puttinan MeepowpanDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-9167-1402

Funding

Fundamental Fund 2025, Chiang Mai UniversityNational Research Council of Thailand N35A650136
6 · The paper itself

Abstract

The emergence of SARS-CoV-2 in 2019 posed significant global public health challenges. One of the most promising targets for novel antiviral drug development is the SARS-CoV-2 main protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesFlavonoidsGallic AcidSARS-CoV-2Binding SitesCOVID-19COVID-19 Drug TreatmentDrug DiscoveryHumansHydrogen BondingMolecular Docking SimulationMolecular Dynamics SimulationProtein Binding3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesFlavonoidsGallic Acidflavonoidsfragment molecular orbitalmolecular dynamicsSARS-CoV-2structural modification

Identifiers

PMID41097008
PMCPMC12524796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.