Evidence map›Paper›PMID 41097007›Full record

ArticleInternational journal of molecular sciences2025

Signaling via C-C Chemokine Ligand 19 and Extracellular Regulated Kinase 5 in T Cells Limits the Humoral Adaptive Immune Response in Mice.

Jaisel A Cervantes, T Paul Welch, Brian Kaiser, Charles A Bill, Angel Torres, Gareth L Bill, Colin A Bill, Charlotte M Vines

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaisel A CervantesDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
T Paul WelchDepartment of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, KS 66103, USA.
Brian KaiserDepartment of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, KS 66103, USA.
Charles A BillDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
Angel TorresDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0009-0002-6935-8847
Gareth L BillDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.
Colin A BillDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0003-0645-0363
Charlotte M VinesDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-7902-8713

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Michael J Kenney · 2019 to 2026
$35.1M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
RISE Scholars Program at UTEPR25GM069621 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2004 to 2021
$11.2M
CCR7 Chemotaxis Regulates Memory T Cell LocalizationSC1GM111172 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI VINES, CHARLOTTE M · 2015 to 2023
$3.0M
NIGMS NIH HHS SC1 GM111172NIH HHS R25GM069621NIH HHS SC1GM111172NIH HHS U54MD007592NIMHD NIH HHS G12 MD007592NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

Misregulation of C-C chemokine receptor 7 (CCR7) has been linked to multiple autoimmune diseases including systemic lupus erythematosus, multiple sclerosis, and ankylosing spondylitis. As a G-protein-coupled receptor, located on the cell membrane, CCR7 can be targeted by inhibiting one of its two ligands, C-C chemokine ligand 19 (CCL19), to regulate its function. In this study, we examined signaling events downstream of CCL19 binding that provide a mechanism for regulation of the immune response. We used a CCR7 antagonist, CCL19

Indexed as

Adaptive ImmunityChemokine CCL19Immunity, HumoralSignal TransductionT-LymphocytesAnimalsFemaleImmunoglobulin GMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR7Ccl19 protein, mouseCcr7 protein, mouseChemokine CCL19Immunoglobulin GReceptors, CCR7autoimmunityC-C chemokine ligand 19C-C chemokine receptor 7extracellular regulated kinase 5

Identifiers

PMID41097007
PMCPMC12525047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.