Evidence map›Paper›PMID 41097006›Full record

ArticleInternational journal of molecular sciences2025

Ezh2 Loss-of-Function Alters Zebrafish Cerebellum Development.

Mariette Hanot, Pamela Völkel, Xuefen Le Bourhis, Chann Lagadec, Pierre-Olivier Angrand

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariette HanotUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.ORCID 0009-0004-7187-3615
Pamela VölkelUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.ORCID 0000-0001-8582-1550
Xuefen Le BourhisUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.ORCID 0000-0001-6790-6358
Chann LagadecUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.ORCID 0000-0002-5182-2069
Pierre-Olivier AngrandUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.ORCID 0000-0002-9509-4796

Funding

Cancéropôle Nord-Ouest Not applicableCentre National de la Recherche Scientifique Not applicableCHU Lille Not applicableInserm Not aplicableLa Ligue Contre le Cancer Not applicableUniversité de Lille Not applicable
6 · The paper itself

Abstract

EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2), plays a critical role in neural development by regulating gene expression through the trimethylation of lysine 27 on histone H3 (H3K27me3), which promotes chromatin remodeling and transcriptional repression. Although PRC2 is known to regulate cell fate specification and gliogenesis, its in vivo functions during vertebrate neurodevelopment, particularly at the level of neuronal subtype differentiation, remain incompletely understood. Here, we investigated the consequences of

Indexed as

CerebellumEnhancer of Zeste Homolog 2 ProteinZebrafishZebrafish ProteinsAnimalsCell DifferentiationCell ProliferationGene Expression Regulation, DevelopmentalLoss of Function MutationNeurogenesisOligodendrogliaEnhancer of Zeste Homolog 2 ProteinZebrafish Proteinsbrain developmentcerebellumEZH2zebrafish

Identifiers

PMID41097006
PMCPMC12524611

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.