Evidence map›Paper›PMID 41096994›Full record

ArticleInternational journal of molecular sciences2025

Properties of Heterochannels Kv(1.1-1.2)

Anastasia A Ignatova, Anastasia V Efremenko, Denis V Abramochkin, Irina Dzhumaniiazova, Ivan I Shmatin, Mikhail P Kirpichnikov, Alexey V Feofanov, Oksana V Nekrasova

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Anastasia A IgnatovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-5217-3937
Anastasia V EfremenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-8263-3009
Denis V AbramochkinFaculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Irina DzhumaniiazovaFaculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0001-5167-2112
Ivan I ShmatinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Mikhail P KirpichnikovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Alexey V FeofanovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-1596-9506
Oksana V NekrasovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-7216-1618

Funding

Russian Science Foundation 25-24-00191
6 · The paper itself

Abstract

Mutation T226R in the Kv1.1 α-subunit of voltage-gated potassium Kv1 channels is associated with episodic ataxia type 1, severe neuromyotonia, and epilepsy. In vitro, this mutation was reported to considerably distort the functioning of homotetrameric channels Kv1.1; however, in the brain, Kv1.1 α-subunits form heterochannels predominantly associating with Kv1.2 α-subunits. Using the patch-clamp technique, fluorescent and Förster resonance energy transfer confocal microscopy, we revealed that heterochannels Kv(1.1(T226R)-1.2)

Indexed as

Kv1.1 Potassium ChannelKv1.2 Potassium ChannelMutationAnimalsCell LineHumansMembrane PotentialsMicePatch-Clamp TechniquesKv1.1 Potassium ChannelKv1.2 Potassium Channelepilepsyepisodic ataxiafluorescent microscopyheterochannelKv1.1Kv1.2mutation in KCNA1patch clamp

Identifiers

PMID41096994
PMCPMC12525039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.