Evidence map›Paper›PMID 41096925›Full record

SynthesisInternational journal of molecular sciences2025

Integrated Meta-Analysis of Scalp Transcriptomics and Serum Proteomics Defines Alopecia Areata Subtypes and Core Disease Pathways.

Li Xi, Elena Peeva, Yuji Yamaguchi, Zhan Ye, Craig L Hyde, Emma Guttman-Yassky

Abstract readMeta-Analysis
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li XiPfizer Inc., Portland St., Cambridge, MA 02139, USA.
Elena PeevaPfizer Inc., Portland St., Cambridge, MA 02139, USA.
Yuji YamaguchiPfizer Inc., Collegeville, PA 19426, USA.ORCID 0000-0003-4338-2662
Zhan YePfizer Inc., Portland St., Cambridge, MA 02139, USA.ORCID 0000-0002-0426-0382
Craig L HydePfizer Inc., Portland St., Cambridge, MA 02139, USA.
Emma Guttman-YasskyDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

Pfizer Inc. GSE148346
6 · The paper itself

Abstract

Alopecia areata (AA) is a chronic autoimmune disorder characterized by non-scarring hair loss, with subtypes ranging from patchy alopecia (AAP) to alopecia totalis and universalis (AT/AU). The aim of this research is to investigate molecular features across AA severity by performing an integrated analysis of scalp transcriptomic datasets (GSE148346, GSE68801, GSE45512, GSE111061) and matched serum proteomic data from GSE148346. Differential expression analysis indicated that, relative to normal scalp, non-lesional AA tissue shows early immune activation-including Type 1 (

Indexed as

Alopecia AreataProteomicsScalpTranscriptomeBiomarkersGene Expression ProfilingHumansBiomarkersalopecia areata (AA)alopecia totalis and universalis (AT/AU)meta-analysispatchy alopecia (AAP)proteomicstranscriptomics

Identifiers

PMID41096925
PMCPMC12525155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.