Evidence map›Paper›PMID 41096919›Full record

ArticleInternational journal of molecular sciences2025

Blood-Brain Barrier Penetration of Novel 4-Trifluoromethyl-Coumarin Hybrids with Antibacterial Properties as Potential Brain Therapeutics in the Context of Spatially Diverse Healthcare Systems.

Paweł Kowalczyk, Dominik Koszelewski, Tomasz Misztal, Michał Szlis, Patrycja Młotkowska, Marcin Gołębiewski, Krzysztof Głowacz, Malwina Kocot, Michał Marczyk, Aleksandra Wypych and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Paweł KowalczykThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0003-4025-3750
Dominik KoszelewskiInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0003-0968-3330
Tomasz MisztalThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0002-2556-4983
Michał SzlisThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.
Patrycja MłotkowskaThe Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0002-5676-1373
Marcin GołębiewskiInstitute of Animal Sciences, Warsaw University of Life Sciences, Nowoursynowska 161, 02-787 Warsaw, Poland.ORCID 0000-0003-0645-433X
Krzysztof GłowaczInstitute of Animal Sciences, Warsaw University of Life Sciences, Nowoursynowska 161, 02-787 Warsaw, Poland.
Malwina KocotFaculty of Management and Organization, Silesian University of Technology, 41-800 Zabrze, Poland.
Michał MarczykDepartment of Data Science and Engineering, Silesian University of Technology, 44-100 Gliwice, Poland.ORCID 0000-0003-2508-5736
Aleksandra WypychCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Toruń, Wileńska 4, 87-100 Toruń, Poland.ORCID 0000-0002-0555-8690
Apoloniusz KurylczykInstitute of Spatial Management and Socio-Economic Geography, University of Szczecin, 70-453 Szczecin, Poland.ORCID 0000-0002-6378-0580
Anna Krajewska-PędzikInstitute of Physical Culture Sciences, University of Szczecin, Piastow 40b/6, 71-065 Szczecin, Poland.
Ryszard OstaszewskiInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-3032-196X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective treatment of central nervous system (CNS) infections remains a major challenge, as most therapeutic agents do not efficiently cross the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). Coumarin derivatives are of particular interest due to their broad pharmacological activity, favorable safety profile, and potential to penetrate biological barriers. Eight novel coumarin-based peptidomimetics functionalized with trifluoromethyl or methyl scaffolds were synthesized and evaluated as antimicrobial agents with the ability to cross the blood-brain barrier. Antimicrobial activity of the investigated compounds was tested against

Indexed as

Anti-Bacterial AgentsBlood-Brain BarrierCoumarinsAnimalsBALB 3T3 CellsEscherichia coliMiceMice, Inbred BALB CMicrobial Sensitivity TestsSheepStaphylococcus aureusAnti-Bacterial AgentsCoumarinsantimicrobial activitycerebrospinal fluidcoumarinsEscherichia coliiminespeptidomimeticsStaphylococcus aureus

Identifiers

PMID41096919
PMCPMC12525028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.