Evidence map›Paper›PMID 41096887›Full record

ArticleInternational journal of molecular sciences2025

Hypercapnia as a Double-Edged Modulator of Innate Immunity and Alveolar Epithelial Repair: A PRISMA-ScR Scoping Review.

Elber Osorio-Rodríguez, José Correa-Guerrero, Dairo Rodelo-Barrios, María Bonilla-Llanos, Carlos Rebolledo-Maldonado, Jhonny Patiño-Patiño, Jesús Viera-Torres, Mariana Arias-Gómez, María Gracia-Ordoñez, Diego González-Betancur and 3 more

Abstract readScoping Review
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. PaCOJournal of clinical medicine · 2026
    Review
  3. Review
  4. Hypercapnic acidosis affectsFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elber Osorio-RodríguezGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.ORCID 0000-0001-9404-5370
José Correa-GuerreroDepartment of Internal Medicine, University of Cartagena, Cartagena de Indias130005, Colombia.ORCID 0000-0002-9736-4913
Dairo Rodelo-BarriosGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.ORCID 0009-0003-8743-3246
María Bonilla-LlanosDepartment of Anesthesiology and Perioperative Medicine, Faculty of Medicine, University of Sabana, Chía 250001, Colombia.
Carlos Rebolledo-MaldonadoDepartment of Intensive Medicine, Clínica Iberoamérica, Barranquilla 080002, Colombia.ORCID 0000-0001-9735-5809
Jhonny Patiño-PatiñoDepartment of Internal Medicine, University of Cartagena, Cartagena de Indias130005, Colombia.
Jesús Viera-TorresDepartment of Intensive Medicine, Clínica Iberoamérica, Barranquilla 080002, Colombia.
Mariana Arias-GómezGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.ORCID 0009-0004-0881-3476
María Gracia-OrdoñezGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.
Diego González-BetancurGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.ORCID 0009-0008-7420-4408
Yassid Nuñez-BeyehGroup of Intensive Care and Comprehensive Care (GRIMICI), Barranquilla 080002, Colombia.ORCID 0009-0000-2268-734X
Gustavo Solano-SopóDepartment of Critical Medicine, Clínica Gestión Salud, Santa Marta 470001, Colombia.
Carmelo Dueñas-CastellIntensive Care and Obstetrics Research Group (GRICIO), University of Cartagena, Cartagena de Indias 130005, Colombia.ORCID 0000-0001-5699-8904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung-protective ventilation and other experimental conditions raise arterial carbon dioxide tension (PaCO

Indexed as

Alveolar Epithelial CellsHypercapniaImmunity, InnatePulmonary AlveoliAnimalsCarbon DioxideHumansSignal TransductionCarbon Dioxidealveolar epithelial repairhypercapniainnate immunityPaCO2scoping review

Identifiers

PMID41096887
PMCPMC12524586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.