Evidence map›Paper›PMID 41096831›Full record

ArticleInternational journal of molecular sciences2025

Candidate Transcript Panel in Semen Extracellular Vesicles Can Improve Prediction of Aggressiveness of Prostate Cancer.

Adriana Ferre-Giraldo, Manel Castells, Alicia Madurga, Ariadna Arbiol-Roca, Maurizio de Rocco-Ponce, Lluís Bassas, Francesc Vigués, Sara Larriba

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adriana Ferre-GiraldoImmune-Inflammatory Processes and Gene Therapeutics Group, Genes, Disease and Therapy Program, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Hospitalet de Llobregat, Barcelona, Spain.ORCID 0009-0004-7099-8168
Manel CastellsUrology Service, Bellvitge University Hospital-ICS, 08908 Hospitalet de Llobregat, Barcelona, Spain.
Alicia MadurgaTerritorial Clinical Laboratory Metropolitan South, Bellvitge University Hospital, 08908 Hospitalet de Llobregat, Barcelona, Spain.ORCID 0009-0006-4293-9923
Ariadna Arbiol-RocaTerritorial Clinical Laboratory Metropolitan South, Bellvitge University Hospital, 08908 Hospitalet de Llobregat, Barcelona, Spain.
Maurizio de Rocco-PonceAndrology Service-Puigvert Foundation, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), 08025 Barcelona, Barcelona, Spain.
Lluís BassasAndrology Service-Puigvert Foundation, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), 08025 Barcelona, Barcelona, Spain.
Francesc ViguésUrology Service, Bellvitge University Hospital-ICS, 08908 Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0003-3717-6301
Sara LarribaImmune-Inflammatory Processes and Gene Therapeutics Group, Genes, Disease and Therapy Program, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0003-4579-5452

Funding

Generalitat de Catalunya 2021SGR052, CES09/020Instituto de Salud Carlos III PI15/00153; DTS18/00101Ministerio de Trabajo y Economía Social 2022-C23.I01.P03.S0020-0000209
6 · The paper itself

Abstract

The need for prostate cancer (PCa)-specific biomarkers that enable more accurate detection of the disease and better prediction of tumor aggressiveness remains ongoing due to the low cancer specificity of PSA screening. Several potential mRNA markers for diagnosing PCa, in tissue and urine, have been reported in the literature. In this study, we aim to explore the potential of selected prostate-specific molecules and transcripts contained in small extracellular vesicles (sEVs) in semen to predict PCa risk reclassification for patients with moderately elevated PSA levels-a clinical scenario where identifying truly non-invasive biomarkers is especially critical. RT-qPCR analysis in semen sEVs successfully showed differential expression of

Indexed as

Biomarkers, TumorExtracellular VesiclesProstatic NeoplasmsSemenAgedAntigens, NeoplasmGene Expression Regulation, NeoplasticHumansKallikreinsMaleMiddle AgedPrognosisProstate-Specific AntigenRNA, MessengerAntigens, NeoplasmBiomarkers, TumorKallikreinsKLK3 protein, humanprostate cancer antigen 3, humanProstate-Specific AntigenRNA, MessengerbiomarkermRNAnon-invasive diagnosis/prognosisprostate cancersemen extracellular vesicles

Identifiers

PMID41096831
PMCPMC12525505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.