Evidence map›Paper›PMID 41096830›Full record

ArticleInternational journal of molecular sciences2025

Developing Up-Scale Allogeneic Chondrocyte Therapies Using Juvenile Donor Cartilage.

Charlotte H Hulme, Jade Perry, Helen S McCarthy, Tian Lan, Thavisha Ranasinghe, Nigel Kiely, Robert Freeman, Jonathan Wright, Karina T Wright

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charlotte H HulmeCentre for Regenerative Medicine Research, School of Life Sciences, Keele University, Keele, Stoke-on-Trent ST5 5BG, Staffordshire, UK.
Jade PerryCentre for Regenerative Medicine Research, School of Life Sciences, Keele University, Keele, Stoke-on-Trent ST5 5BG, Staffordshire, UK.ORCID 0000-0002-5953-1389
Helen S McCarthyCentre for Regenerative Medicine Research, School of Life Sciences, Keele University, Keele, Stoke-on-Trent ST5 5BG, Staffordshire, UK.ORCID 0000-0001-9534-7565
Tian LanCentre for Regenerative Medicine Research, School of Life Sciences, Keele University, Keele, Stoke-on-Trent ST5 5BG, Staffordshire, UK.
Thavisha RanasingheOswestry Keele Orthopaedic Research Group, Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry SY10 7AG, Shropshire, UK.
Nigel KielyOswestry Keele Orthopaedic Research Group, Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry SY10 7AG, Shropshire, UK.
Robert FreemanOswestry Keele Orthopaedic Research Group, Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry SY10 7AG, Shropshire, UK.
Jonathan WrightLimb Reconstruction Unit, Royal National Orthopaedic Hospital, Stanmore, London HA7 4LP, UK.ORCID 0000-0001-6055-648X
Karina T WrightCentre for Regenerative Medicine Research, School of Life Sciences, Keele University, Keele, Stoke-on-Trent ST5 5BG, Staffordshire, UK.

Funding

Medical Research Council MR/S015167/1National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre
6 · The paper itself

Abstract

Allogeneic chondrocyte therapies present an attractive alternative to existing autologous therapies for the repair of cartilage defects, enabling the selection of optimal donor cells and streamlined manufacturing processes. This study investigates the potential of juvenile chondrocytes derived from human infantile (aged 0-4 y) polydactyly digits and the iliac apophysis for cartilage repair using Good Manufacturing Practice bioreactor expansion. Iliac apophysis (

Indexed as

CartilageChondrocytesBioreactorsCell Culture TechniquesCells, CulturedChild, PreschoolChondrogenesisGlycosaminoglycansHumansInfantInfant, NewbornMaleTissue DonorsTransplantation, HomologousGlycosaminoglycansallogeneic cell therapycartilage cell repairchondrocyteshollow-fibre bioreactoriliac apophysis chondrocyteslarge-scale expansionpolydactyly chondrocytes

Identifiers

PMID41096830
PMCPMC12525350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.