Evidence map›Paper›PMID 41096823›Full record

ArticleInternational journal of molecular sciences2025

Dysferlin Protein-Protein Interaction Pathways in the Organ of Corti and Spiral Ganglion Intersect with Alzheimer's Protein Pathways.

Marian J Drescher, Dennis G Drescher, Khalid M Khan, James S Hatfield, Darshi Hemani

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marian J DrescherLaboratory of Bio-Otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Dennis G DrescherLaboratory of Bio-Otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Khalid M KhanLaboratory of Bio-Otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
James S HatfieldLaboratory of Bio-Otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Darshi HemaniLaboratory of Bio-Otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Funding

Jain Foundation and NIH Grants DC004076, DC000156
6 · The paper itself

Abstract

Dysferlin direct protein-protein interactions (PPI) previously have been elucidated with surface plasmon resonance (SPR) and predicted to underlie membrane repair in mechanotransducing myofibrils. In mechanotransducing inner ear hair cells, dysferlin is detected with Z-stack confocal immunofluorescence in the stereocilia and their inserts in the tectorial membrane (TM) co-localizing with FKBP8, consistent with the SPR determination of tight, positively Ca

Indexed as

Alzheimer DiseaseDysferlinOrgan of CortiProtein Interaction MapsSpiral GanglionAnimalsCalciumHumansSignal TransductionCalciumDysferlinAlzheimer’s diseaseBCL2dysferlin protein–protein interactionsFKBP8ryanodine receptorssurface plasmon resonancetectorial membrane

Identifiers

PMID41096823
PMCPMC12524998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.