Evidence map›Paper›PMID 41096814›Full record

ArticleInternational journal of molecular sciences2025

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications.

Francesco Canonico, Renzo Laborante, Chiara Pidone, Ramona Vinci, Mattia Galli, Eugenia Pisano, Alice Bonanni, Marianna Di Sario, Anna Severino, Lucia Lisi and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesco CanonicoDepartment of Thoracic and Cardiovascular Diseases, Azienda Ospedaliero-Universitaria Maggiore Della Carità, 28100 Novara, Italy.ORCID 0000-0001-6936-4548
Renzo LaboranteDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Chiara PidoneDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0003-0822-7499
Ramona VinciDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Mattia GalliDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-3909-182X
Eugenia PisanoDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Alice BonanniDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0001-8382-255X
Marianna Di SarioDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Anna SeverinoDepartment of Cardiovascular Sciences, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
Lucia LisiDepartment of Pharmacology, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0003-1397-2426
Daniela PedicinoDepartment of Cardiovascular Sciences, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-4218-3066
Giovanna LiuzzoDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Massimiliano RuscicaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-0195-7061
Filippo CreaDepartment of Cardiovascular and Pneumological Sciences, Catholic University of Sacred Heart, 00168 Rome, Italy.
Giuseppe PattiDepartment of Thoracic and Cardiovascular Diseases, Azienda Ospedaliero-Universitaria Maggiore Della Carità, 28100 Novara, Italy.ORCID 0000-0002-5404-3968
Domenico D'AmarioDepartment of Thoracic and Cardiovascular Diseases, Azienda Ospedaliero-Universitaria Maggiore Della Carità, 28100 Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PLIN2 is involved in the lipid metabolism of macrophages resident in atherosclerotic plaques, and its upregulation leads to lipid droplets (LDs) accumulation. LDs enlargement results in the macrophage transformation into foam cells, a key step for the onset of atherosclerosis. In the present study, we investigated the role of PLIN2 and its regulation mechanisms in atherosclerosis and plaque instability in patients with a diagnosis of ST-elevation myocardial infarction (STEMI) and chronic coronary syndrome (CCS). We enrolled STEMI (

Indexed as

Acute Coronary SyndromeMonocytesPerilipin-2AgedChronic DiseaseFemaleHumansLipid MetabolismMaleMiddle AgedPlaque, AtheroscleroticProteasome Endopeptidase ComplexPerilipin-2PLIN2 protein, humanProteasome Endopeptidase ComplexCCSoxidative stressplaque instabilityPLIN2proteasome activitySTEMI

Identifiers

PMID41096814
PMCPMC12524928

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.