Evidence map›Paper›PMID 41096813›Full record

ReviewInternational journal of molecular sciences2025

Emerging Paradigms in Cholesteatoma: From a Traditional Approach to Personalized Therapy.

Adina Zamfir-Chiru-Anton, Dana Manda, Dan-Cristian Gheorghe

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adina Zamfir-Chiru-Anton"Grigore Alexandrescu" Emergency Hospital for Children, 011743 Bucharest, Romania.ORCID 0000-0001-6269-9126
Dana Manda"C.I. Parhon" National Institute of Endocrinology, 011863 Bucharest, Romania.
Dan-Cristian GheorgheFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesteatoma is a prevalent disease affecting both children and adults. In this review, we present the recent findings related to the molecular mechanisms involved in cholesteatoma and discuss how researchers can target new molecules to treat this disease. These new approaches illustrate the paradigm shift from a primarily surgical solution to a biological "control and prevent" strategy.

Indexed as

Cholesteatoma, Middle EarMolecular Targeted TherapyOtologic Surgical ProceduresPrecision MedicineAnimalsCell ProliferationDisease Models, AnimalEar, MiddleEpigenesis, GeneticExtracellular MatrixHumansKeratinocytesMicroRNAsMolecular Diagnostic TechniquesOsteogenesisRecurrenceMicroRNAscholesteatomamiddle earpersonalized medicine

Identifiers

PMID41096813
PMCPMC12525388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.