Evidence map›Paper›PMID 41096801›Full record

Observational studyInternational journal of molecular sciences2025

Estimating the Contribution of Renal Function to Endothelial Dysfunction and Subclinical Inflammation with a Two-Cohort Study: Living Kidney Donors and Their Transplant Recipients.

Irina B Torres, Carla Burballa, José M González-Posada, Domingo Hernández, Esteban Porrini, Janire Perurena, Vicente Cortina, Manel Perelló, Dolores Redondo-Pachón, Ana González-Rine and 6 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02515643 (Estimating the Contribution of Renal Function to Endothelial Dysfunction by a Two-cohort Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02515643 unknown statusnot on this map

Estimating the Contribution of Renal Function to Endothelial Dysfunction by a Two-cohort Study: Living Kidney Donors and Their Transplant Recipients

TypeobservationalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2015 to 2017Enrolled120ConditionsDisorder Related to Renal Transplantation, Chronic Kidney Disease, Endothelial DysfunctionArmsEndothelial dysfunction
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Irina B TorresNephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Carla BurballaNephrology Department, Hospital del Mar-Parc de Salut Mar, 08003 Barcelona, Spain.
José M González-PosadaNephrology Department, Hospital Universitario de Canarias, 38320 La Laguna-Tenerife, Spain.
Domingo HernándezNephrology Department, Hospital Regional Universitario Carlos Haya, 29010 Málaga, Spain.ORCID 0000-0001-5469-2119
Esteban PorriniInstituto de Tecnologías Biomédicas, University of La Laguna, 38320 La Laguna-Tenerife, Spain.
Janire PerurenaImmunology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Vicente CortinaHematology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Manel PerellóNephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-1859-5279
Dolores Redondo-PachónNephrology Department, Hospital del Mar-Parc de Salut Mar, 08003 Barcelona, Spain.
Ana González-RineNephrology Department, Hospital Universitario de Canarias, 38320 La Laguna-Tenerife, Spain.
Mercedes CabelloNephrology Department, Hospital Regional Universitario Carlos Haya, 29010 Málaga, Spain.
Maria José Pérez-SáezNephrology Department, Hospital del Mar-Parc de Salut Mar, 08003 Barcelona, Spain.ORCID 0000-0002-8601-2699
Marta CrespoNephrology Department, Hospital del Mar-Parc de Salut Mar, 08003 Barcelona, Spain.
Oriol BestardNephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Daniel SerónNephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Francesc MoresoNephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0002-7267-3963

Funding

TEVA Spain S.L. Grant for the study: (NCT02515643
6 · The paper itself

Abstract

Living kidney transplantation offers the best results for end-stage renal disease patients, but concerns about cardiovascular risk after nephrectomy for kidney donors have been raised. We aimed to estimate the contribution of renal function to endothelial dysfunction (ED) and subclinical inflammation in a non-interventional, prospective, multicenter, longitudinal study with two cohorts: living kidney donors and their transplant recipients (registered clinical trial NCT02515643). The measured glomerular filtration rate (mGFR) by iohexol clearance, estimated GFR according to the CKD-EPI and MDRD-4 formulas, and levels of endothelial dysfunction (sVCAM-1, sICAM-1, E-selectin, von Willebrand Factor, pentraxin, and urinary albumin-to-creatinine ratio) and subclinical inflammation biomarkers (sIL-6, sTNF-R1, sTNF-R2, sTWEAK, and high-sensitivity C-reactive protein) were determined at baseline and 1-year follow-up. Fifty pairs of donors and recipients were recruited between 2015 and 2018. Among the endothelial dysfunction biomarkers, sVCAM-1 increased in donors and decreased in recipients (

Indexed as

Endothelium, VascularInflammationKidneyKidney TransplantationLiving DonorsAdultBiomarkersFemaleGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesTransplant RecipientsBiomarkersendothelial dysfunctioninflammationiohexol clearancekidney transplantationliving donorrenal function

Identifiers

PMID41096801
PMCPMC12525258

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.