ReviewInternational journal of molecular sciences2025
Dynamic Hydrogels: Adaptive Biomaterials for Engineering Tumor Microenvironment and Cancer Treatment.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photocontrolled Drug Release From Donor-Acceptor Stenhouse Adduct Amphiphile Doped Laden Polymeric Hydrogel.Macromolecular rapid communications · 2026Article
- Light-activated thiomaleimide crosslinking stabilizes collagen mimetic peptide triple helix.Chemical communications (Cambridge, England) · 2026Article
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Bridging biomaterials and immunotherapy: hydrogel strategies for next-generation CAR-T cell treatment.Stem cell research & therapy · 2026Review
- Hydrogel-based delivery systems for cutaneous melanoma therapy: from chemical design and crosslinking strategies to structure-activity relationships.RSC advances · 2026Review
- Review
- Next-Generation Hydrogel Platforms for Effective Localized Cancer Therapy: Advances in Biologics, Immunotherapeutics, and Gene Delivery.Oncology research · 2026Review
- Hydrogel-Based Immunomodulation of Tumor Immune Microenvironment in Hepatocellular Carcinoma: Current Strategies and Future Directions.International journal of nanomedicine · 2026Review
- Mechanism-Inspired Biomaterials and Regenerative Therapies for Radiation-Induced Skin Injury.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dynamic hydrogels are revolutionizing tumor microenvironment (TME) engineering through their stimuli-responsive adaptability, mechanical tunability, and capacity for multifunctional integration. In addition, they are excellent biomaterials for cancer treatments, including their biomimetic properties and controlled cargo release capability. This review introduces the rational design and principles of dynamic hydrogels for recreating the tumor microenvironment and cancer therapy, including natural/synthetic hydrogels, multi-stimuli responsive hydrogels, and multi-drug loading hydrogels. These designs emphasize their unique roles in overcoming drug resistance, enhancing immunotherapy, and enabling patient-specific models. We highlight breakthroughs such as dual-responsive nanocomposites and microfluidic-integrated 3D platforms while addressing translational hurdles like cytotoxicity and regulatory delays. By proposing strategies to bridge material science with clinical needs, this work positions dynamic hydrogels as pivotal tools for next-generation precision oncology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.