Evidence map›Paper›PMID 41096759›Full record

ArticleInternational journal of molecular sciences2025

Evaluation of Potential Molecular Targets of the Alkaloid Epiisopiloturine, Involved in Cardioprotective Effects, Using Computational Molecular Docking in an Animal Model of Cardiac Ischemia and Reperfusion.

Francisco Sandro Menezes-Rodrigues, Elisa Andrade Costa, Pedro Ivo De Marqui Moraes, Erisvaldo Amarante de Araújo, Carlos Eduardo Braga Filho, Leiz Maria Costa Véras, Paulo Sérgio de Araujo Sousa, Jefferson Almeida Rocha, Nelson Americo Hossne Junior, Solange Guizilini and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Francisco Sandro Menezes-RodriguesPostgraduate Program in Interdisciplinary Surgical Science, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.ORCID 0000-0001-7913-0585
Elisa Andrade CostaPostgraduate Program in Interdisciplinary Surgical Science, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.ORCID 0009-0000-1517-8918
Pedro Ivo De Marqui MoraesPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.
Erisvaldo Amarante de AraújoPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.
Carlos Eduardo Braga FilhoPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.ORCID 0000-0002-4884-4013
Leiz Maria Costa VérasResearch Center on Biodiversity and Biotechnology, Universidade Federal do Delta do Parnaíba (UFDPar), Parnaíba 64202-020, PI, Brazil.
Paulo Sérgio de Araujo SousaResearch Center on Biodiversity and Biotechnology, Universidade Federal do Delta do Parnaíba (UFDPar), Parnaíba 64202-020, PI, Brazil.ORCID 0000-0001-8764-4455
Jefferson Almeida RochaResearch Center on Biodiversity and Biotechnology, Universidade Federal do Delta do Parnaíba (UFDPar), Parnaíba 64202-020, PI, Brazil.ORCID 0000-0001-6619-2293
Nelson Americo Hossne JuniorCardiovascular Surgery Discipline, Universidade Federal de São Paulo, São Paulo 04024-002, SP, Brazil.
Solange GuiziliniPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.
Isadora S RoccoPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.
Walter José GomesPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.
Afonso Caricati-NetoDepartment of Pharmacology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.
Marcelo Pires-OliveiraDepartment of Medicine, Centro Universitário UNIME, Lauro de Freitas 42700-000, BA, Brazil.ORCID 0000-0002-5839-1265
Célia Maria Camelo SilvaPostgraduate Program in Cardiology, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.ORCID 0000-0003-3857-9890
Almir Gonçalves WanderleyDepartment of Pharmaceutical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50740-520, PE, Brazil.ORCID 0000-0001-5193-1153
Fernando Sabia TalloPostgraduate Program in Interdisciplinary Surgical Science, Universidade Federal de São Paulo (UNIFESP), São Paulo 04024-000, SP, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/25565-1
6 · The paper itself

Abstract

The most common cause of morbidity and death worldwide is acute myocardial infarction (AMI), which is typified by severe and deadly arrhythmias resulting from cardiac ischemia and reperfusion (CIR). We chose to investigate the possible cardioprotective activity of epiisopiloturine (EPI), an imidazole alkaloid presents in the leaves of

Indexed as

AlkaloidsCardiotonic AgentsImidazolesMolecular Docking SimulationMyocardial IschemiaMyocardial Reperfusion InjuryAnimalsArrhythmias, CardiacCreatine Kinase, MB FormDisease Models, AnimalElectrocardiographyMaleMyocardial InfarctionRatsRats, WistarAlkaloidsCardiotonic AgentsCreatine Kinase, MB FormImidazolescardiac diseasescardiac ischemia–reperfusionepiisopiloturinemyocardial infarctionpharmacological cardioprotection

Identifiers

PMID41096759
PMCPMC12525413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.