Evidence map›Paper›PMID 41096741›Full record

ArticleInternational journal of molecular sciences2025

The Significance and Mechanism of Cerebral Enlarged Perivascular Space in Amyotrophic Lateral Sclerosis.

Bo-Ching Lee, Yih-Chih Kuo, Lo-Fan Cheng, Yi-Chieh Tsai, Jia-Zheng Huang, Hsin-Hsi Tsai, Jhih-Syuan Lin, Po-Ya Huang, Chen-Hung Ting, Chih-Chao Yang and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bo-Ching LeeDepartment of Medical Imaging, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0002-1443-928X
Yih-Chih KuoDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Lo-Fan ChengDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Yi-Chieh TsaiDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Jia-Zheng HuangDepartment of Medical Imaging, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0009-0003-5823-0108
Hsin-Hsi TsaiDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Jhih-Syuan LinDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Po-Ya HuangDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Chen-Hung TingGarage Brain Science, B201, Central Taiwan Innovation Campus, Ministry of Economic Affairs, Nantou City 540219, Taiwan.
Chih-Chao YangDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Hsing-Jung LaiDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Chi-Chao ChaoDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.
Li-Kai TsaiDepartment of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan.

Funding

National Health Research Institutes NHRI-112-B02)National Science and Technology Council 113-2314-B-002-100-MY3National Taiwan University Hospital MS484
6 · The paper itself

Abstract

Enlarged perivascular spaces (EPVS) are MRI markers of impaired glymphatic clearance and have been associated with neurodegenerative diseases. However, their clinical significance in amyotrophic lateral sclerosis (ALS) and underlying mechanisms remain poorly understood. This study investigated the prevalence, clinical relevance, and pathophysiological basis of EPVS in ALS. MRI data from 114 ALS patients and 119 matched controls were analyzed, with high-degree EPVS defined as more than 20 visible spaces. High-degree EPVS in the centrum semiovale (CSO) was more prevalent in ALS patients (49.1%) than in controls (15.1%,

Indexed as

Amyotrophic Lateral SclerosisGlymphatic SystemAdultAgedAnimalsDisease Models, AnimalFemaleHumansMagnetic Resonance ImagingMaleMiceMice, TransgenicMiddle AgedMotor NeuronsSuperoxide Dismutase-1Superoxide Dismutase-1amyotrophic lateral sclerosis (ALS)animal modelenlarged perivascular spacemagnetic resonance imaging (MRI)misfolded proteinsuperoxide dismutase type 1

Identifiers

PMID41096741
PMCPMC12524775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.