Evidence map›Paper›PMID 41096721›Full record

ArticleInternational journal of molecular sciences2025

Early Use of Innovative Biomarkers Such as Mid-Regional Pro-Adrenomedullin and SeptiCyte

Chiara Risso, Lorenzo Vay, Francesca Sciascia, Riccardo Traversi, Marco Ellena, Anna Chiara Trompeo, Luca Brazzi, Giorgia Montrucchio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiara RissoDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.
Lorenzo VayDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.
Francesca SciasciaDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.
Riccardo TraversiDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0009-0001-4604-5197
Marco EllenaAnestesia e Rianimazione 1 U, Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, 10126 Turin, Italy.
Anna Chiara TrompeoAnestesia e Rianimazione 1 U, Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, 10126 Turin, Italy.
Luca BrazziDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-7059-0622
Giorgia MontrucchioDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-9341-965X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognostic uncertainty and missed diagnoses of sepsis remain frequent after cardiopulmonary bypass (CPB) surgery, where systemic inflammatory response (SIRS) arises from surgical trauma, blood activation in the extracorporeal circuit, ischemia/reperfusion injury, and endotoxin release. Among innovative biomarkers, pro-adrenomedullin (pro-ADM), particularly its stable fragment mid-regional pro-adrenomedullin (MR-proADM), has shown promise for detecting endothelial dysfunction and predicting organ failure in sepsis. SeptiCyte

Indexed as

AdrenomedullinBiomarkersCardiac Surgical ProceduresProtein PrecursorsSepsisAgedCardiopulmonary BypassFemaleHumansMaleMiddle AgedPeptide FragmentsPilot ProjectsPostoperative ComplicationsProcalcitoninAdrenomedullinBiomarkersmid-regional pro-adrenomedullin, humanPeptide FragmentsProcalcitoninProtein Precursorsbiomarkerscardiopulmonary bypassendocarditisendothelial dysfunctionhost gene responsehost immune responseinflammatory responseintensive care unitmidregional pro-adrenomedullinSeptiCyte RAPID

Identifiers

PMID41096721
PMCPMC12525275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.