Evidence map›Paper›PMID 41096681›Full record

ArticleInternational journal of molecular sciences2025

Distinct Intrinsic and Extrinsic Factors Differentially Regulate Skeletal Stem Cells in Calvaria Versus Long Bones During Bone Regeneration.

Jea Solidum, Kohei Yamasaki, Youngjae Jeong, Laura Ortinau, Francisco Heralde, Dongsu Park

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jea SolidumDepartment of Molecular Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-7161-2106
Kohei YamasakiDepartment of Molecular Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-0881-8857
Youngjae JeongDepartment of Molecular Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Laura OrtinauDepartment of Molecular Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-8036-8459
Francisco HeraldeDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines, Manila 1000, Philippines.
Dongsu ParkDepartment of Molecular Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.ORCID 0000-0002-2570-3250

Funding

Regulation of Skeletal progenitor cells in Osteogenesis ImperfectaR01DE031288 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee, Dongsu Park · 2022 to 2026
$3.3M
WNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal TissuesR01DE031162 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, PARK, DONGSU · 2021 to 2025
$2.9M
Defining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1M
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR61AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2020 to 2021
$694k
NIAMS NIH HHS R01 AR072018NIAMS NIH HHS R01AR072018NIAMS NIH HHS R61AR078073NIDCR NIH HHS R01 DE031162NIDCR NIH HHS R01 DE031288NIDCR NIH HHS R01DE031288
6 · The paper itself

Abstract

Calvarial suture skeletal stem cells (Su-SSCs) are a distinct stem cell population for craniofacial bone formation by intramembranous ossification, compared to long bone periosteal SSCs (LB-PSSCs) with endochondral (osteochondrogenic) ossification. However, whether SSC intrinsic or extrinsic factors affect their differentiation process has not been well elucidated. Here, using an inducible

Indexed as

Bone RegenerationSkullStem CellsAnimalsCell DifferentiationChondrogenesisHomeodomain ProteinsMiceOsteogenesisHomeodomain ProteinsPrrx1 protein, mousecell transplantationchondrogenesiscraniomaxillofacialPrx1skeletal stem cellssuture stem cells

Identifiers

PMID41096681
PMCPMC12525401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.