ArticleInternational journal of molecular sciences2025
Selective Degradation and Inhibition of SARS-CoV-2 3CL
Hyun Lee, Yunjeong Hwang, Elizabeth J Mulder, Yuri Song, Calista Choi, Lijun Rong, Dimitri T Azar, Kyu-Yeon Han
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Hyun LeeDepartment of Pharmaceutical Science, College of Pharmacy & Biophysics Core, the Research Resource Center, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-2570-8120 Yunjeong HwangDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
Elizabeth J MulderBiophysics Core, the Research Resource Center, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-8613-2340 Yuri SongBiophysics Core, the Research Resource Center, University of Illinois Chicago, Chicago, IL 60607, USA.
Calista ChoiBiophysics Core, the Research Resource Center, University of Illinois Chicago, Chicago, IL 60607, USA.
Lijun RongDepartment of Microbiology and Immunology, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
Dimitri T AzarDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
Kyu-Yeon HanDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
Funding
Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AAKALU, VINAY · 1985 to 2025
$14.8MIdentification of a new role of membrane‐type 1 matrix metalloproteinases in corneal neovascularizationR01EY033758 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Kyuyeon Han · 2023 to 2026
$1.6MDevelopment of MMP14-laden exosomes as a novel anti-SARS-CoV-2 therapyR21AI168744 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HAN, KYUYEON · 2023 to 2024
$440kNEI NIH HHS P30 EY001792NEI NIH HHS R01 EY033758NIAID NIH HHS R21 AI168744NIH HHS 1R01EY010101-02
6 · The paper itselfAbstract
Novel therapies to treat infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of respiratory coronavirus disease 2019 (COVID-19), would be of great clinical value to combat the current and future pandemics. Two viral proteases, papain-like protease (PL
Indexed as
Coronavirus 3C ProteasesCysteine EndopeptidasesMatrix Metalloproteinase 14Viral Nonstructural ProteinsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentHumansPandemicsProteolysisSARS-CoV-23C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesMatrix Metalloproteinase 14MMP14 protein, humanViral Nonstructural Proteins3CLproenzyme inhibitionMMP14SARS-CoV-2
Identifiers
PMID41096670
PMCPMC12524713
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