ArticleInternational journal of molecular sciences2025
Hepatocellular EVs Regulate Lipid Metabolism via SIRT1/SREBP-1c/PGC-1α Signaling in Primary Calf Hepatocytes.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
SIRT1-SREBP-1c/PGC-1α signaling is involved in the production of non-esterified fatty acids (NEFAs) and liver lipid metabolism disorders in ketotic calf. The molecules contained in extracellular vesicles (EVs) regulate intercellular communication, and research on calf hepatocytes-derived EVs has become a hot spot. We hypothesized that EVs in cell culture supernatants could affect lipid metabolism in hepatocyte models via SIRT1/SREBP-1c/PGC-1α signaling. Non-ketosis (NK, 0 mM NEFA) and clinical ketosis calf models (CK, 2.4 mM NEFAs) were established in vitro cultured calf hepatocytes and EVs were extracted from their supernatants as NK-derived EVs and CK-derived EVs, respectively. In vitro hepatocyte models, comprising a normal culture group (normal) and the group treated with NEFAs at 2.4 mM (2.4 NEFA), were treated with NK and CK-derived EVs. In addition, we transfected an SIRT1-overexpressing adenovirus into calf hepatocytes and determined the expression of key genes, enzymes, and proteins involved in the SIRT1/SREBP-1c/PGC-1α pathway. The results showed that the NK-derived EVs inhibited the expression of the SREBP-1c gene and protein and increased the expression of the SIRT1 and PGC-1α genes and proteins (
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