ArticleInternational journal of molecular sciences2025
Distance-Dependent Distribution of Biomarkers in Colorectal Cancer Tissues: In Vivo Study.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colorectal cancer (CRC) is among the most prevalent and deadly malignancies worldwide. Despite advancements in screening and treatment, its aggressive progression and tendency to metastasize remain major challenges. Biomarkers such as cathepsins B and D, actin isoforms, and cysteine protease inhibitors may influence tumor invasion and metastasis. However, little is known about their spatial distribution in tumor versus surrounding tissue. This study aimed to evaluate the location-dependent expression of selected biomarkers in CRC tissue to better understand their role in cancer progression. Tissue samples were obtained intraoperatively from 37 CRC patients at three locations: the tumor center, and 2 cm and 5 cm from the tumor margin. The activity and concentrations of cathepsins B and D, anti-papain activity, and actin fractions (globular [G-], filamentous [F-], and total actin [T-actin]) were measured using biochemical and spectrophotometric assays. Statistical analyses included ANOVA, MANOVA, and non-parametric tests, with significance set at
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