Evidence map›Paper›PMID 41096633›Full record

ArticleInternational journal of molecular sciences2025

Transcriptional Regulation of

Lucas W Picavet, Hisham I Abu-Tawil, Lyanne J P M Sijbers, Jorg J A Calis, Nienke Ter Haar, Alejandra Bodelón, Sebastiaan J Vastert, Jorg van Loosdregt

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas W PicavetCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.ORCID 0009-0003-0638-720X
Hisham I Abu-TawilCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.ORCID 0000-0001-6351-5034
Lyanne J P M SijbersCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.ORCID 0009-0009-1015-164X
Jorg J A CalisCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.
Nienke Ter HaarCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.
Alejandra BodelónCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.ORCID 0000-0003-2361-8156
Sebastiaan J VastertCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.ORCID 0000-0002-4226-0949
Jorg van LoosdregtCenter for Translational Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands.

Funding

This research was funded by the Dutch arthritis society (ReumaNederland) LLP10
6 · The paper itself

Abstract

N6-methyladenosine (m6A) is a dynamic RNA modification that critically modulates gene expression in immune responses. While m6A regulators such as WTAP are implicated in inflammatory and autoimmune diseases, the mechanisms governing their expression during innate immune activation remain unclear. Here, we demonstrate that

Indexed as

Gene Expression RegulationMonocytesNF-kappa BSignal TransductionTranscription Factor RelATranscription, GeneticAdenosineHumansLipopolysaccharidesPromoter Regions, GeneticProtein IsoformsAdenosineLipopolysaccharidesNF-kappa BN-methyladenosineProtein IsoformsTranscription Factor RelAinflammationisoformsLPSm6Amonocyte activationNF-κB signalingRNA methylationWTAP

Identifiers

PMID41096633
PMCPMC12524415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.