Evidence map›Paper›PMID 41096629›Full record

ArticleInternational journal of molecular sciences2025

MyD88 Plays an Important Role in UVB-Induced Suppression of Dendritic Cell Activity, T Cell Function, and Cutaneous Immune Response.

Mohammad Asif Sherwani, Carlos Alberto Mier Aguilar, Charlotte McRae, Gelare Ghajar-Rahimi, Aisha Anwaar, Ahmed Omar Jasser, Ariq Chandra, Hui Xu, Nabiha Yusuf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad Asif SherwaniDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.ORCID 0000-0001-5317-1557
Carlos Alberto Mier AguilarDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.
Charlotte McRaeHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0009-0009-6129-8289
Gelare Ghajar-RahimiHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Aisha AnwaarDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.ORCID 0009-0007-1557-6490
Ahmed Omar JasserDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.ORCID 0009-0006-4494-4398
Ariq ChandraDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.
Hui XuDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.ORCID 0000-0002-7989-6932
Nabiha YusufDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, VH 566A, Birmingham, AL 35294-0019, USA.ORCID 0000-0001-5730-0037

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
NCI NIH HHS P30 CA013148NIH HHS AI157398-01
6 · The paper itself

Abstract

Ultraviolet B (UVB) radiation triggers DNA damage and immune suppression, establishing conditions favorable for skin carcinogenesis. Previous studies have shown that a downstream adaptor for Toll-like receptors (TLRs), myeloid differentiation primary response 88 (MyD88), plays a role in UVB-induced DNA damage and immunosuppression. However, specific mechanisms for the effects on dendritic cells and T cells remain poorly understood. The objective of this study is to determine the role of MyD88 and TIR-domain-containing adaptor inducing interferon-β (TRIF), another key TLR downstream adaptor, in UVB-induced suppression of dendritic cell activity and T cell function.

Indexed as

Dendritic CellsMyeloid Differentiation Factor 88SkinT-LymphocytesUltraviolet RaysAdaptor Proteins, Vesicular TransportAnimalsMiceMice, Inbred C57BLMice, KnockoutT-Lymphocytes, RegulatoryAdaptor Proteins, Vesicular TransportMyd88 protein, mouseMyeloid Differentiation Factor 88Ticam1 protein, mouseDNA damageimmune suppressionMyD88TRIFultraviolet radiation

Identifiers

PMID41096629
PMCPMC12524367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.