Evidence map›Paper›PMID 41096602›Full record

ArticleInternational journal of molecular sciences2025

Cytokine and Chemokine-Associated Signatures Underlying Dermal Invasion and Skin Metastasis in Melanoma.

Viktória Koroknai, István Szász, Tünde Várvölgyi, Gabriella Emri, Ádám Fodor, Margit Balázs

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Viktória KoroknaiDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary.ORCID 0000-0001-8090-6643
István SzászDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary.
Tünde VárvölgyiDepartment of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Gabriella EmriDepartment of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-2877-4740
Ádám FodorHUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary.
Margit BalázsDepartment of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4028 Debrecen, Hungary.ORCID 0000-0002-4246-2321

Funding

European Regional Development Fund GINOP-2.3.2-15-2016-00005Hungarian Research Network TKCS-2021/32National Research Development and Innovation Fund K-135752University of Debrecen Program for Scientific Publication and by the University of Debrecen Scientific Research Bridging Fund DETKAUniversity Research Scholarship Program of the Ministry for Culture and Innova-tion from the source of the National Research Development and Innovation Fund EKÖP-24-4
6 · The paper itself

Abstract

Metastatic spread remains the primary cause of mortality in melanoma. Our aim was to investigate the role of dermal endothelial cells in modulating melanoma cell invasiveness and cytokine/chemokine pattern. Primary melanoma cell lines were co-cultured with human dermal endothelial cells and assessed using Matrigel invasion assays. Invasive and non-invasive subpopulations were separated for gene expression analyses, and candidate molecules were further evaluated in patient tissue and plasma samples. Co-culture of melanoma and dermal endothelial cells revealed altered expression of several cytokine receptor genes (

Indexed as

ChemokinesCytokinesMelanomaSkin NeoplasmsCell Line, TumorCoculture TechniquesEndothelial CellsFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisChemokinesCytokineschemokinescytokinesdermal endotheliumIL1RAPL2IL6STmelanomametastasisMidkineTNFRSF10A

Identifiers

PMID41096602
PMCPMC12524697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.