Evidence map›Paper›PMID 41096601›Full record

ArticleInternational journal of molecular sciences2025

In Vitro and In Vivo Comparative Analysis of Muscle Regenerative Processes Induced by Different Microcurrent Waveforms in Skeletal Muscle Atrophy.

Yoon-Jin Lee, Eun Sang Kwon, Yong Suk Moon, Dong Rak Kwon

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoon-Jin LeeDepartment of Biochemistry, College of Medicine, Soonchunhyang University, Cheonan 31511, Republic of Korea.ORCID 0000-0001-6364-1284
Eun Sang KwonDepartment of Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.ORCID 0009-0005-2666-5902
Yong Suk MoonDepartment of Anatomy, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea.
Dong Rak KwonDepartment of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea.ORCID 0000-0003-4728-930X

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (MEST) 2022R1A2C2091162
6 · The paper itself

Abstract

This study aimed to evaluate the regenerative effects of various microcurrent waveforms in cast-induced gastrocnemius muscle atrophy in rabbits, integrating both in vitro and in vivo analyses. After two weeks of enforced hindlimb immobilization via casting, twenty-four rabbits were divided into four groups and treated for two weeks: Group-1 (control) received sham microcurrent, Group-2 was treated with a square waveform microcurrent, Group-3 with a sine waveform, and Group-4 with a triangular waveform. Treatments were administered daily for one hour. Calf circumference, muscle thickness (via ultrasound), tibial nerve CMAP, muscle fiber CSA, and protein expression (via Western blot analysis) were assessed. Among the groups, the sine waveform microcurrent resulted in significantly enhanced recovery across all measured parameters (

Indexed as

Electric Stimulation TherapyMuscle, SkeletalMuscular AtrophyRegenerationAnimalsApoptosisCell ProliferationMaleRabbitsmicrocurrentmuscle atrophyrabbit modelskeletal muscle regenerationwaveforms

Identifiers

PMID41096601
PMCPMC12525230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.