SynthesisInternational journal of molecular sciences2025
Adipocyte-Derived Stem Cells in the Treatment of Spinal Cord Injuries in Animal Models: A Systematic Review.
Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stem Cell-based Nerve Regenerative Therapies: The Role of Adipose-Derived Stem Cells (ADSCs) in Preventing Nerve Adhesions and Promoting Axonal Nerve Repair.Stem cell reviews and reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI) represents a burdensome and currently incurable condition which affects over 20 million patients globally. Adipocyte-derived mesenchymal stem cell (ADSC) therapy may constitute a valuable strategy in treating this condition, owing to their unique cellular characteristics and beneficial effects on functional recovery. This PRISMA (Preferred Reporting Items for Systematic Reviews) review aims to assess whether ADSC therapy is a viable strategy for treating SCI in animal models. We identified a total of 1561 studies after performing a search of four databases, including PubMed, Web of Science, Scopus and Medline. After applying inclusion and exclusion criteria, we identified a total of 16 articles that were reviewed, assessed and reported in our study. General characteristics of these studies, results of stem cell characterisation, SCI induction protocols, locomotor recovery and bladder function following SCI, were investigated as part of our analysis. Fifteen studies suggested that ADSC therapy has a beneficial effect on motor recovery following SCI. The evidence base regarding adjuvant therapies was, however, variable. Further investigations into the mechanisms that underly recovery following ADSC therapy, and potential adjuvants which could enhance these effects, should follow the outcomes of this systematic review. In turn, this would help expand the treatment options available to SCI patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.